{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:21:42Z","timestamp":1784892102567,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072015"],"award-info":[{"award-number":["82072015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Large to giant congenital melanocytic nevi (LGCMN) significantly decrease patients' quality of life, but the inaccuracy of current classification system makes their clinical management challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To improve and extend the existing LGCMN 6B\/7B classification systems by developing a novel LGCMN classification system based on a new phenotypic approach to clinical tool development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and sixty\u2010one LGCMN cases were categorized into four subtypes based on anatomic site: bonce (25.48%), extremity (17.73%), shawl (19.67%) and trunks (37.12%) LGCMN. A \u2018BEST\u2019 classification system of LGCMN was established and validated by a support vector machine classifier combined with the 7B system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common LGCMN distributions were on bonce and trunks (bathing trunk), whereas breast\/belly and body LGCMN were exceptionally rare. Sexual dimorphism characterized distribution, with females showing a wider range of lesions in the genital area. Nearly half of the patients with bathing trunk LGCMN exhibited a butterfly\u2010like distribution. Approximately half of the LGCMN with chest involvement did not have nipple\u2013areola complex involvement. Abdomen, back and buttock involvement was associated with the presence of satellite nevi (<jats:italic>r<\/jats:italic>\u2009=\u20090.558), and back and buttock involvement was associated with the presence of nodules (<jats:italic>r<\/jats:italic>\u2009=\u20090.364).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effective quantification of a standardized anatomical site provides data support for the accuracy of the 6B\/7B classification systems. The simplified BEST classification system can help establish a LGCMN clinical database for exploration of LGCMN aetiology, disease management and prognosis prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20075","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T10:09:56Z","timestamp":1714990196000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A BEST classification system of large to giant congenital melanocytic nevi based on expert consensus and distribution characteristics"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-3086","authenticated-orcid":false,"given":"Ge","family":"Song","sequence":"first","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University  Xiamen China"},{"name":"Department of Plastic Surgery First Affiliated 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Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-4161","authenticated-orcid":false,"given":"Wuping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1989-2508","authenticated-orcid":false,"given":"Pengfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2137-2646","authenticated-orcid":false,"given":"Yongqiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery 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