{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:09:49Z","timestamp":1792026589643,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scarce data related to the drug survival of biologic agents in psoriasis patients aged \u226565\u2009years is available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the drug survival of interleukin (IL)\u201023 or the IL\u201017 inhibitors approved for the treatment of moderate\u2010to\u2010severe psoriasis in elderly patients (aged \u226565\u2009years), compared with younger adult patients (aged &lt;65\u2009years), and to identify clinical predictors that can influence the drug survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicentric cohort study included adult patients with moderate\u2010to\u2010severe psoriasis, dissecting two\u2010patient subcohorts based on age: elderly versus younger adults. Kaplan\u2013Meier estimator and proportional hazard Cox regression models were used for drug survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 4178 patients and 4866 treatment courses; 934 were elderly (1072 treatment courses), and 3244 were younger patients (3794 treatment courses). Drug survival, considering all causes of interruption, was higher in patients aged &lt;65\u2009years than in elderly patients overall (log\u2010rank <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.006). This difference was significant for treatment courses involving IL\u201023 inhibitors (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not for those with IL\u201017 inhibitors (<jats:italic>p<\/jats:italic>\u2009=\u20090.2). According to both uni\u2010 and multi\u2010variable models, elder age was associated with an increased risk of treatment discontinuation (univariable analysis: HR: 1.229, 95% CI 1.062\u20131.422; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.006; multivariable analysis: HR: 1.199, 95% CI 1.010\u20131.422; <jats:italic>p<\/jats:italic>\u2009=\u20090.0377). Anti\u2010IL\u201023 agents were associated with a reduced likelihood of treatment discontinuation after adjusting for other variables (HR: 0.520, 95% CI 0.368\u20130.735; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Being previously treated with IL\u201017 inhibitors increased the probability of discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly patients with psoriasis have an increased risk of biologic treatment discontinuation compared with younger adult patients, particularly, if being treated with IL\u201023 inhibitors. However, in stratified analyses conducted in elderly patients, IL\u201023 inhibitors showed higher drug survival rates than IL\u201017 inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20143","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:31:33Z","timestamp":1718130693000},"page":"2175-2185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Age affects drug survival rates of interleukin (<scp>IL<\/scp>)\u201017 and <scp>IL<\/scp>\u201023 inhibitors in patients with plaque psoriasis: Results from a retrospective, multicentric, multi\u2010country, cohort study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-0387","authenticated-orcid":false,"given":"Andrea","family":"Chiricozzi","sequence":"first","affiliation":[{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica Del Sacro Cuore  Rome Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Coscarella","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universit\u00e0 Cattolica Del Sacro Cuore  Rome Italy"},{"name":"Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-0952","authenticated-orcid":false,"given":"Luis","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-2724","authenticated-orcid":false,"given":"Ron","family":"Vender","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Probity Medical Research University of Toronto  Waterloo Ontario 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