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Thirty\u2010six included articles studied patients who received HFUS (\u226510\u2009MHz) measurements, melanoma biopsy or excision, and reported a tumour depth correlation coefficient between HFUS and histopathology. We analysed correlation coefficients between HFUS and histopathology, measured tumour depths and shed light on reasons for mismeasurements. Additionally, we identified the reporting of critical metrics including, lesion characteristics, melanoma subtype, type of correlation coefficient, 95% confidence intervals for Pearson coefficients and sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common tumour imaged was superficial spreading melanoma on the trunk and extremities, followed by head\/face. Maximum ultrasound frequencies ranged from 13\u2009MHz to 100\u2009MHz with participants ranging from 5 to 264. Histopathology and HFUS correlation coefficients ranged from 0.417 to 0.997 (median: 0.94, mean: 0.89 and SD: 0.13). Lower frequency probes (10\u201320\u2009MHz) were less accurate in assessing melanoma thickness, with a cumulative mean correlation coefficient of 0.87 compared to 0.94 (20\u201325\u2009MHz) and 0.98 (\u226570\u2009MHz). Studies demonstrated higher sonographic accuracy in melanomas &gt;0.75\u2009mm.<\/jats:p><jats:p>Additionally, ultrasound may report increased melanoma depth compared to histopathology for reasons including lymphocytic infiltration, presence of a nevus and shrinkage during specimen processing. Furthermore, we found a gap in the reporting of details such as fundamental characteristics of lesion populations. Specifically, 86% (31 out of 36) of the studies failed to report one or more critical metrics, such as mean, median or range of lesion depths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HFUS may serve as a supplementary tool for preoperative melanoma assessment, with increased accuracy in thicker tumours. Frequencies &lt;20\u2009MHz are less reliable in assessing depth. Frequencies \u226570\u2009MHz demonstrate stronger correlations to histopathology. Higher ultrasound accuracy was seen for melanomas with Breslow depth &gt;0.75\u2009mm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20179","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T15:25:50Z","timestamp":1720193150000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["High\u2010frequency ultrasound accuracy in preoperative cutaneous melanoma assessment: A meta\u2010analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-5825","authenticated-orcid":false,"given":"Georgina E.","family":"Sellyn","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee 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