{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:58Z","timestamp":1787015518527,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial (FP) and genital psoriasis (GP) significantly affect patients' quality of life. Despite the advances in treatments, limited data on efficacy and safety are available on these difficult\u2010to\u2010treat areas. Guselkumab is an interleukin (IL)\u201023 inhibitor which has been proven effective in treating patients with moderate\u2010to\u2010severe plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this interim analysis was to report the efficacy and safety of guselkumab in the treatment of patients with FP and\/or GP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>GULLIVER is a 52\u2010week Italian observational study to evaluate the effectiveness and safety of guselkumab in a real\u2010life setting in patients with FP and\/or GP. Adult patients with facial and\/or genital moderate\u2010to\u2010severe psoriasis (sPGA score\u2009\u2265\u20093) were included. The primary endpoint of this analysis was the percentage of patients achieving a facial or genital sPGA score of 0 (clear) or 1 (almost clear), at Week 12. The change in the score of the facial or genital sPGA components in patients with a score \u22653 for each sPGA component was assessed. PASI score in patients with a baseline PASI above or below 10 was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 351 patients were included in the study; 83.3% of FP and 76.5% of GP patients achieved the primary endpoint. Similar response rates were observed for the facial or genital sPGA components in patients with a baseline facial or genital sPGA score \u22653 in each component. Among patients with a baseline PASI score &gt;10, mean PASI score improved from 19.0 (SD 8.3) to 2.2 (SD 4.8). Forty\u2010four AEs were observed in 32 patients; two mild and transient AEs (fatigue and nausea) were considered treatment related. No SAEs were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Guselkumab, showing to be effective and safe in treating FP and GP, may be a valid therapeutic option for patients with psoriasis localized in these difficult\u2010to\u2010treat areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20187","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:16:50Z","timestamp":1719397010000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness of guselkumab in patients with facial and\/or genital psoriasis: Interim analysis results at Week 12 from the GULLIVER study"],"prefix":"10.1111","volume":"39","author":[{"given":"C.","family":"Bonifati","sequence":"first","affiliation":[{"name":"Department of Clinical Dermatology San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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