{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:09:10Z","timestamp":1773101350316,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous pemphigoid (BP) affects older patients with numerous comorbidities. The impact of BP on patient autonomy remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the frequency and factors associated with functional decline (FD) in BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective monocentric study, we selected patients aged \u226575\u2009years with BP diagnosed between 1 January 2015 and 31 December 2021 and followed for more than 3\u2009months. We assessed activity limitation at diagnosis and included patients with no or mild activity limitation. We described FD and its associated factors at 6\u2009weeks and 3\u2009months. FD was qualified as moderate or severe. Age, comorbidities (CIRS\u2010G score), BP characteristics at diagnosis (including palms and soles involvement) and hospitalization were collected. Factors associated with FD were investigated through univariate and multivariate logistic regression models. Worsening of previous comorbidities or new comorbidities at Week 6 were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and thirty\u2010one patients were included (mean age 85\u2009years), 75 (57.3%) had no activity limitation, and 56 (42.7%) a mild activity limitation at baseline. At Week 6, FD was observed in 44 (33.6%) patients, including 23 out of 75 (30.7%) with no activity limitation and 21 out of 56 (37.5%) with mild activity limitation at baseline. FD was moderate in 20 cases (45.5%) and severe in 24 (54.5%) and persisted at Month 3 in 37 (84%) patients. By multivariate analysis, factors associated with FD were a CIRS\u2010G score &gt;7, palms and soles involvement and anti\u2010BP180 antibodies level. Fifty (38.2%) patients experienced a worsening of their pre\u2010existing comorbidities or a new one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FD is often observed in patients with BP, especially in those with severe symptoms, palms and soles involvement and comorbidities. A comprehensive, multidisciplinary approach involving geriatric assessments should be adopted to manage these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20231","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:09:05Z","timestamp":1719918545000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Functional decline among bullous pemphigoid patients: A retrospective monocentric cohort study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6954-7150","authenticated-orcid":false,"given":"R.","family":"Ouakrat","sequence":"first","affiliation":[{"name":"D\u00e9partement de Dermatologie, AP\u2010HP H\u00f4pitaux Universitaires Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Peiffer","sequence":"additional","affiliation":[{"name":"D\u00e9partement M\u00e9dico\u2010Universitaire \u2018Medecine\u2019, AP\u2010HP H\u00f4pitaux Universitaires Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Evaluation of Therapeutics (EpiDermE) \u2013 EA 7379 Universit\u00e9 Paris Est Cr\u00e9teil (UPEC)  Cr\u00e9teil France"},{"name":"Centre d'investigation Clinique CIC\u20101430 H\u00f4pitaux Universitaires Henri\u2010Mondor, Univ Paris Est Creteil  Creteil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Canou\u00ef\u2010Poitrine","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sant\u00e9 Publique, AP\u2010HP H\u00f4pitaux Universitaires Henri Mondor  Cr\u00e9teil France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB, Equipe CEpiA (Clinical Epidemiology and Ageing)  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7096","authenticated-orcid":false,"given":"S.","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Dermatologie, AP\u2010HP H\u00f4pitaux Universitaires Henri Mondor  Cr\u00e9teil 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