{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:16:43Z","timestamp":1778887003122,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical trials and real\u2010life data have reported an increased incidence of conjunctivitis in patients treated with dupilumab for their atopic dermatitis (AD). Although mostly mild in severity, in some cases conjunctivitis will appear or increase after dupilumab initiation, which can lead to dupilumab discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To describe the characteristics of patients developing conjunctivitis requiring discontinuation of dupilumab; and (2) to analyse the factors associated with a complete conjunctivitis improvement after dupilumab discontinuation and a switch to tralokinumab or Janus kinase inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicentre retrospective cohort study that included all patients with AD treated with dupilumab who developed conjunctivitis leading to dupilumab discontinuation and switching to tralokinumab or Janus kinase inhibitors in daily practice. Data on patients, their AD and conjunctivitis were analysed at the inclusion visit (corresponding to discontinuation of dupilumab and the institution of new AD treatment), at visit 2 (3\u20136\u2009months after inclusion) and at visit 3 (corresponding to the last medical visit).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After multivariate analysis, the only factors associated with a complete resolution of dupilumab\u2010associated conjunctivitis at visit 2 and\/or visit 3 were conjunctivitis duration (OR 8.98, 95% CI 1.47\u201355) (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), personal history of asthma (OR 10.66, 95% CI 1.82\u201362.63) (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) and switching from dupilumab to Janus kinase inhibitors (OR 17.11, 95% CI 2.94\u201399.66) (<jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although uncommon, severe dupilumab\u2010associated conjunctivitis is more frequent in daily life compared to its incidence in the dupilumab pivotal trials. In these cases, our study suggests that a rapid switch to another molecule, particularly a Janus kinase inhibitor, should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20233","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:35:14Z","timestamp":1721201714000},"page":"2149-2155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evolution of dupilumab\u2010associated conjunctivitis in patients with atopic dermatitis after switching dupilumab to tralokinumab or Janus kinase inhibitors (<scp>RESO<\/scp>\u2010<scp>ADOC<\/scp> study)"],"prefix":"10.1111","volume":"38","author":[{"given":"Ziad","family":"Reguiai","sequence":"first","affiliation":[{"name":"Department of Dermatology Polyclinique Courlancy  Reims\u2010Bezannes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Andr\u00e9","family":"Becherel","sequence":"additional","affiliation":[{"name":"Dermatology and Clinical Immunology Unit Antony Hospital  Antony France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"CHU Saint Etienne  Saint\u2010Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Boulard","sequence":"additional","affiliation":[{"name":"Centre Hospitalier du Havre  Le Havre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-867X","authenticated-orcid":false,"given":"Anne Claire","family":"Fougerousse","sequence":"additional","affiliation":[{"name":"H\u00f4pital d'Instruction Des Arm\u00e9es Begin  Saint Mand\u00e9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Begon","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Ren\u00e9 Dubos  Pontoise France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Badaoui","sequence":"additional","affiliation":[{"name":"Cabinet M\u00e9dical  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Poreaux","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dical Stanislas  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Parier","sequence":"additional","affiliation":[{"name":"Cabinet M\u00e9dical  Saint\u2010Maur\u2010des\u2010Foss\u00e9s France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Liegeon","sequence":"additional","affiliation":[{"name":"Centre Hospitalier r\u00e9gional Metz\u2010Thionville  Thionville France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Levavasseur","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Annecy Genevois  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