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Despite numerous indications of gender\u2010 and sex\u2010specific influences on the treatment of dermatological conditions, these have not yet been systematically investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To meet this unmet need, we conducted the present systematic review on the topic of gender and sex differences in the treatement outcome of skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Embase (via Ovid), PubMed Medline and Web of Science were searched, in between January 2001 and December 2022. English and german randomized controlled trials, prospective and retrospective cohorts and case\u2013control studies that examined differences between men and women in treatment outcomes of skin diseases were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two authors independently screened the reports for eligibility, one extracted all data (the second double\u2010checked) and critically appraised the quality and risk of bias of the studies. Eighty\u2010three reports were included. The largest share of the identified publications focused on gender differences in psoriasis and psoriatic arthritis (<jats:italic>n<\/jats:italic>\u2009=\u200949), followed by melanoma (<jats:italic>n<\/jats:italic>\u2009=\u20098) and sporadic studies (<jats:italic>n<\/jats:italic>\u2009&lt;\u20095) of inflammatory, infectious and autoimmune skin diseases. The main topics in which gender differences could be identified were choice of treatment, time to initiation of treatment, therapy response, adverse events, adherence and treatment satisfaction. For psoriasis, gender differences could be found in all aspects, while for the other skin diseases specific publications on gender differences are still missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review shows numerous gender differences but also reveals major gaps in gender\u2010specific care in dermatology which should be narrowed in the upcoming years to optimize a patient\u2010centred, individualized, gender\u2010equal healthcare. 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