{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:29:12Z","timestamp":1793035752738,"version":"4.5.0"},"reference-count":80,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Nakaseomyces glabratus<\/jats:italic>\n                      (\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      ) formerly known as\n                      <jats:italic>Candida glabrata<\/jats:italic>\n                      (\n                      <jats:italic>C.\u2009glabrata<\/jats:italic>\n                      ), is an endogenous opportunistic pathogen, which is generally located in the gastrointestinal tract but can spread in immunocompromised patients.\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      is the second most common pathogen that causes candidemia in several countries.\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      virulence factors may increase antifungal resistance and reduce the number of available treatment options. High resistance to azoles and increasing resistance to echinocandins have been previously reported in\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To establish the distribution of\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      isolates in Europe and its drug susceptibility\/resistance in each country over the last 7\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The search was performed across three databases: PubMed, Scopus and Scielo, using the MeSH terms: \u201c\n                      <jats:italic>Candida glabrata<\/jats:italic>\n                      \u201d, \u201c\n                      <jats:italic>Nakaseomyces glabratus<\/jats:italic>\n                      \u201d, \u201cEurope\u201d, \u201cresistance\u201d and \u201cEpidemiology\u201d exclusively in English. All available information from January 2002 to December 2022 was included, excluding reviews, meta\u2010analyses and book chapters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010seven articles with information on antifungal susceptibility in Europe were retrieved and analysed with a total of 15,400 reported\n                      <jats:italic>C.\u2009glabrata<\/jats:italic>\n                      isolates. Remarkably, nations that presented the maximum number of cases during the study period included the United Kingdom (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097241, 47.02%), France (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093190, 20.71%), Spain (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009900, 5.84%), Hungary (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009745, 4.84%) and Italy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009486, 3.16%).\n                      <jats:italic>C.\u2009glabrata<\/jats:italic>\n                      isolates presented resistance to azoles [voriconazole (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092225, 14.45%), fluconazole (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091612, 10.47%), itraconazole (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009337, 2.19%) and clotrimazole (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200989, 0.58%)], increased resistance to echinocandins, especially to anidulafungin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009138, 0.89%), and high sensitivity to amphotericin B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The number of candidemia cases associated with triazole\u2010resistant\n                      <jats:italic>N.\u2009glabratus<\/jats:italic>\n                      isolates have been increasing in Europe. Therefore, echinocandins and amphotericin B can be considered optional empirical treatments; however, antifungal susceptibility testing is required to determine the best therapeutic options.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20273","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:17:30Z","timestamp":1723540650000},"page":"377-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Virulence and resistance factors of\n                    <i>Nakaseomyces glabratus<\/i>\n                    (formerly known as\n                    <i>Candida glabrata<\/i>\n                    ) in Europe: A systematic review"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-0771","authenticated-orcid":false,"given":"Carmen","family":"Rodr\u00edguez\u2010Cerdeira","sequence":"first","affiliation":[{"name":"Dermatology Department Hospital Vithas Vigo  Vigo Spain"},{"name":"Fundaci\u00f3n Vithas Grupo Hospitalario Vithas  Madrid Spain"},{"name":"Department of Health Sciences University of Vigo  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-5395","authenticated-orcid":false,"given":"Rodolfo","family":"Pinto\u2010Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Vithas Grupo Hospitalario Vithas  Madrid Spain"},{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-1047","authenticated-orcid":false,"given":"Ditte M. 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