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The Dermatology Life Quality Index (DLQI) is the most widely used tool to measure the burden of skin diseases and assess effectiveness of interventions based on patients' perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to systematically analyse peer\u2010reviewed publications describing use of the DLQI in validation of other patient\u2010reported outcome (PRO) and quality\u2010of\u2010life (QoL) measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven databases were searched for papers published between January 1994 and December 2022 for articles containing data using DLQI in the validation of other PRO\/QoL measures. The methodology followed PRISMA guidelines. The protocol was prospectively registered on PROSPERO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1717 screened publications, 122 articles including 30,727 patients from 34 different countries with 41 diseases met the inclusion criteria. The DLQI was used in validation of 101 measures: 80 dermatology\u2010specific QoL measures, mostly disease\u2010specific, and 21 generic measures. Of these studies, 47 were cross\u2010cultural adaptations, 116 single arm, 100 were cross\u2010sectional, 18 longitudinal and six randomized placebo controlled. DLQI was used for 14 known group, and correlation for 10 construct, 101 convergent, 10 concurrent, 10 divergent\/discriminant and three criterion validity tests using Mann\u2013Whitney (2), Spearman's (80), Pearson's correlation (26) and Student's <jats:italic>t<\/jats:italic>\u2010test (1). The DLQI was used in responsiveness analysis in 13 studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review identified widespread use of the DLQI in validation of other dermatology PRO\/QoL measures and confirmed the central role that the DLQI plays as a benchmark in instrument development and validation across dermatology and beyond. The use of the DLQI by so many developers of other instruments has provided a common standard for comparability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20321","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T10:26:58Z","timestamp":1726223218000},"page":"631-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Dermatology Life Quality Index (<scp>DLQI<\/scp>) used as the benchmark in validation of 101 quality\u2010of\u2010life instruments: A\u00a0systematic review"],"prefix":"10.1111","volume":"39","author":[{"given":"J.","family":"Vyas","sequence":"first","affiliation":[{"name":"Centre for Medical Education, School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-4306","authenticated-orcid":false,"given":"J. 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