{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:45:23Z","timestamp":1788432323442,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methotrexate (MTX) has been a longstanding therapeutic option for mycosis fungoides (MF); however, data on its real\u2010world effectiveness remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate treatment\u2010related outcomes of oral MTX in patients with early\u2010 and late\u2010stage MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective multicentre analysis involving MF subjects from five referral centres for cutaneous lymphomas in Greece. Data regarding the effectiveness and safety were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 211 MF patients were enrolled (males, 68.3%) with a median (IQR) age of diagnosis at 68.3 (56\u201375) years. Late\u2010stage (IIB\u2010IVB) disease was present in 124 patients (59.3%). MTX monotherapy was administered to 112 (53.1%) patients, with 99 receiving combination regimens with phototherapy, interferon and retinoids. MTX was used as first\u2010line regimen in 103 (48.9%) cases. An overall response rate (ORR) of 55.5% was observed with 29.9% of patients achieving complete responses. MTX demonstrated greater effectiveness as a first\u2010line treatment compared to subsequent use with no significant differences between monotherapy and combination therapy. The median time to best response was 3.8\u2009months (IQR 2.3\u20139.9\u2009months). Patients with erythrodermic disease (Stage III) had better ORRs compared to patients with tumour stage disease (Stage II) (61.1% vs. 44.8% respectively). The progression\u2010free survival (PFS) varied according to stage, with a median PFS of 17.1\u2009months for early\u2010stage disease, 5.7\u2009months for Stage IIB disease, 46\u2009months for Stage III and 9.6\u2009months for Stage IV disease (0.7\u2010.). Serious adverse (Grade 3) events leading to treatment discontinuation occurred in 14 (6.7%) cases. All patients received oral MTX once weekly with a median weekly dose of 15\u2009mg\/week (7.5\u201325).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support MTX as a viable treatment option for MF, particularly when used in the first\u2010line setting, offering a favourable benefit\/risk profile. Response rates are stage\u2010dependent, with erythrodermic patients achieving superior and durable responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20350","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T05:20:55Z","timestamp":1726723255000},"page":"1442-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness and safety of methotrexate in the treatment of mycosis fungoides: Real\u2010world data from a multicentre study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9152","authenticated-orcid":false,"given":"Vasiliki","family":"Nikolaou","sequence":"first","affiliation":[{"name":"1st Department of Dermatology \u201cAndreas Syggros\u201d Hospital for Skin Diseases, National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-3889","authenticated-orcid":false,"given":"Evdoxia","family":"Panou","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology \u201cAndreas Syggros\u201d Hospital for Skin Diseases, National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-0762","authenticated-orcid":false,"given":"Antonios","family":"Tsimpidakis","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology \u201cAndreas Syggros\u201d Hospital for Skin Diseases, National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-7139","authenticated-orcid":false,"given":"Ioannis\u2010Alexios","family":"Koumprentziotis","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology \u201cAndreas Syggros\u201d Hospital for Skin Diseases, National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-2001","authenticated-orcid":false,"given":"Aikaterini","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinics, 2nd Dermatology Department Aristotle University School of Medicine, Papageorgiou General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Siakantaris","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Laikon General Hospital, National &amp; Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine\u2010Elke","family":"Kruger\u2010Krasagakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology University General Hospital of Heraklion  Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Marinos","sequence":"additional","affiliation":[{"name":"Hemopathology Department \u201cEvangelismos\u201d General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinics, 2nd Dermatology Department Aristotle University School of Medicine, Papageorgiou General Hospital  Thessaloniki Greece"},{"name":"Laboratory of Biological Chemistry Aristotle Universitiy, School of Medicine  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Lampadaki","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology \u201cAttikon\u201d General Hospital, National &amp; 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Kapodistrian University of Athens, Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-00809-w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00135.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113343"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3719"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)01591-3"},{"issue":"11","key":"e_1_2_12_7_1","first-page":"3586","article-title":"Methotrexate in the treatment of mycosis fungoides \u2013 a multicenter observational study in 79 patients","volume":"22","author":"Olek\u2010Hrab K","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2019.1558399"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30379-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy207"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80062-4"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2014.06.005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2007.0402"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802562427"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845415Y.0000000002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16567"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.106206"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.01.054"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540200600203"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T07:21:03Z","timestamp":1754292063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.20350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jdv.20350"],"URL":"https:\/\/doi.org\/10.1111\/jdv.20350","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"2024-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}