{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:42Z","timestamp":1787015562841,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hailey\u2013Hailey disease (HHD) is a rare genetic therapy\u2010resistant blistering disease with great disease burden. Treatment is currently focused on symptomatic relief. Er:YAG ablative laser therapy is a therapeutic modality with promising results, though evidence is currently scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the effect of Er:YAG ablative laser therapy on clinical remission of erosive plaques in HHD and on patient's quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational study eight patients were included and 77 erosive plaques were treated once only by Er:YAG laser and assessed for clinical remission. QoL was evaluated by obtaining Skindex\u201029 and DLQI questionnaires before laser therapy, 6\u2009weeks and 3\u2009years after laser therapy. Skin biopsies were taken to evaluate the depth of laser ablation. The intercellular distance between keratinocytes, the number of desmosomes and intermediate filament distribution were studied by electron microscopy before and after laser therapy and in clinically uninvolved skin and were compared to subjects without HHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One single Er:YAG laser ablation to mid\u2010dermis resulted in complete remission of 97.4% of HHD plaques (75\/77) after median 38\u2009months (range 7\u201363\u2009months) and significantly improved QoL. Laser therapy restored the number of desmosomes, decreased intercellular distance and diminished perinuclear retraction of keratin filaments to a level comparable to the patient's clinically uninvolved skin. After laser ablation, the skin showed significantly fewer ultrastructural aberrations compared to the patient's clinically uninvolved skin and rather resembled the skin of healthy control individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One single Er:YAG laser treatment resulted in long\u2010term remission of HHD and significantly improved QoL. Our findings support a greater role for ablative laser surgery in the management of this recalcitrant disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20351","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T05:14:21Z","timestamp":1727759661000},"page":"1038-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term remission of Hailey\u2013Hailey disease by Er:\n                    <scp>YAG<\/scp>\n                    ablative laser therapy"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2028-2973","authenticated-orcid":false,"given":"Marie\u2010Eline P. H.","family":"Debeuf","sequence":"first","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e8vin","family":"Knoops","sequence":"additional","affiliation":[{"name":"Microscopy CORE Lab, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"L\u00f3pez\u2010Iglesias","sequence":"additional","affiliation":[{"name":"Microscopy CORE Lab, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Lookermans","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-7353","authenticated-orcid":false,"given":"Patty J.","family":"Nelemans","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrurgia","family":"Abdul Hamid","sequence":"additional","affiliation":[{"name":"Department of Pathology Maastricht University Medical Centre+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"van Geel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht The Netherlands"},{"name":"Department of Clinical Genetics Maastricht University Medical Centre+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-2914","authenticated-orcid":false,"given":"Antoni H.","family":"Gostynski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Steijlen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre of Expertise for Genodermatoses Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW Research Institute for Oncology and Developmental Biology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke C.","family":"Bolling","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Groningen, UMCG Centre of Expertise for Genodermatoses and European Reference Network\u2010Skin University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie L. 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