{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:49:08Z","timestamp":1789480148468,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immune checkpoint inhibitors (ICI) are considered standard\u2010of\u2010care in the systemic treatment of melanoma. However, management of certain ICI\u2010associated adverse events (AE) can be challenging. Incidence, course and management of immune checkpoint inhibitor\u2010induced pancreatic injury (ICIPI) are not well\u2010documented and specific diagnostic and therapeutic algorithms are lacking. Current management includes serological monitoring of pancreatic enzymes, radiographic imaging and corticosteroid or further immunosuppressive treatment. Objectives: Based on previous data regarding adjuvant ICI treatment, we suspected that elevation of pancreatic enzymes may occur more frequently than reported while the clinical relevance of\u2014particularly asymptomatic\u2014ICIPI is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A collaboration of eight Austrian and Swiss dermato\u2010oncology centres was established to retrospectively analyse a large cohort of ICI\u2010treated patients regarding incidence and management of ICIPI. Additionally, a questionnaire\u2010based survey concerning ICIPI\u2010management was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1516 melanoma patients receiving ICI therapy, 204 patients exhibited \u2265CTCAE II\u00b0 lipase elevation. Of these patients, 41 (20.1%) had symptoms suggestive of pancreatitis. Immunotherapy was interrupted or discontinued due to pancreatic AE in almost half of the patients. Systemic corticosteroids were administered in 103 patients (50.5%), with higher doses reported in symptomatic cases. Six per cent of asymptomatic patients had radiographically proven pancreatitis. Maximum lipase elevation was &gt;5xULN in all of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine lipase monitoring was conducted in all participating centres, although not recommended in respective guidelines. Elevation of serum lipase was observed more frequently than recently reported. Although radiographic findings indicating pancreatitis were rare in asymptomatic patients, ICI treatment was frequently paused or discontinued and systemic steroids were administered. To reduce the existing uncertainty in routine clinical practice reflected by our findings, we provide an algorithm to guide the monitoring and management of potential pancreatic adverse events. Lipase measurement should be limited to symptomatic patients and\/or those with radiographic findings indicative of pancreatic injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.20384","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T07:37:54Z","timestamp":1732088274000},"page":"1656-1665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immune checkpoint inhibitor\u2010induced pancreatic enzyme elevation in melanoma patients: Incidence, management and therapy\u2014A multicentre analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0210-5065","authenticated-orcid":false,"given":"M.","family":"Brandlmaier","sequence":"first","affiliation":[{"name":"Department for Dermatology and Allergology Paracelsus Medical University Hospital Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hoellwerth","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Allergology Paracelsus Medical University Hospital Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Silly","sequence":"additional","affiliation":[{"name":"Department for Dermatology Medical University Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hoeller","sequence":"additional","affiliation":[{"name":"Department for Dermatology Medical University Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-5411","authenticated-orcid":false,"given":"L.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Medical University Graz  Klagenfurt am W\u00f6rthersee Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Richtig","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Medical University Graz  Klagenfurt am W\u00f6rthersee Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Binder","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Hospital Klagenfurt  Klagenfurt am W\u00f6rthersee Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lange\u2010Asschenfeldt","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Hospital Klagenfurt  Klagenfurt am W\u00f6rthersee Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barta","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Wels\u2010Grieskirchen Hospital  Wels Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schmid\u2010Simbeck","sequence":"additional","affiliation":[{"name":"Department for Dermatology Klinik Donaustadt  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Department for Dermatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-6906","authenticated-orcid":false,"given":"R.","family":"Dummer","sequence":"additional","affiliation":[{"name":"Department for Dermatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Muigg","sequence":"additional","affiliation":[{"name":"Department for Dermatology and Venerology Hospital Wiener Neustadt  Wiener Neustadt Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Hitzl","sequence":"additional","affiliation":[{"name":"Research and Innovation Management (RIM) Paracelsus Medical University Salzburg  Salzburg Austria"},{"name":"Department of Ophthalmology and Optometry Paracelsus Medical University Salzburg  Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology &amp; 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