{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:52:39Z","timestamp":1783032759977,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The surging rates of STIs necessitate medical practitioners in the appropriate specialties to focus on rapid recognition, treatment and prevention of these conditions. Through both pre\u2010 and post\u2010exposure prophylaxis with doxycycline, dermatologists can provide up\u2010to\u2010date treatment in the field of venereology. Herein, we review the results of clinical trials in the available literature that investigate doxycycline prophylaxis in the prevention of bacterial STIs. A search was performed using the PubMED and Scopus databases which yielded six clinical trials for our review. Based on the results of these clinical trials, doxycycline prophylaxis offers significant reductions in bacterial STIs, specifically in men who have sex with men (MSM). Additional research is needed in other high\u2010risk groups, including females. Moreover, additional research is needed to determine the effects of doxycycline prophylaxis on tetracycline resistance in STI\u2010causing bacteria. As the utilization of doxycycline prophylaxis for STIs becomes more common, it is important that dermatologists become familiar with the data surrounding this prevention regimen and patient populations who may seek to know more about it. More research is needed to determine benefits in other subpopulations, antimicrobial resistance and cost effectiveness.<\/jats:p>","DOI":"10.1111\/jdv.20387","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T12:29:44Z","timestamp":1731932984000},"page":"1091-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Review of doxycycline for prophylaxis of sexually transmitted infections"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-9454","authenticated-orcid":false,"given":"Scott","family":"Stratman","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-4567","authenticated-orcid":false,"given":"John G.","family":"Zampella","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"issue":"4","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1353\/bhm.1997.0179","article-title":"The Kaposi's sarcoma clinic at the University of California, San Francisco: an early response to the AIDS epidemic","volume":"71","author":"Hughes SS","year":"1997","journal-title":"Bull Hist Med"},{"key":"e_1_2_13_3_1","unstructured":"STI cases on the rise across Europe: European Centre for Disease Prevention and Control.2024. Atlanta GA. 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Atlanta GA. 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NEW YORK CITY DEPARTMENT OF HEALTH AND MENTAL HYGIENE.2023.https:\/\/www.nyc.gov\/assets\/doh\/downloads\/pdf\/std\/dear\u2010colleague\u2010doxy\u2010PEP\u2010to\u2010prevent\u2010bacterial\u2010STI\u201011092023.pdf"},{"issue":"46","key":"e_1_2_13_37_1","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2023.28.46.2300621","article-title":"Using doxycycline for prophylaxis of bacterial sexually transmitted infections: considerations for the European Union and European Economic Area","volume":"28","author":"Mardh O","year":"2023","journal-title":"Euro Surveill"},{"issue":"4","key":"e_1_2_13_38_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/OLQ.0000000000001130","article-title":"High interest in syphilis pre\u2010exposure and post\u2010exposure prophylaxis among gay, bisexual and other men who have sex with men in Vancouver and Toronto","volume":"47","author":"Fusca L","year":"2020","journal-title":"Sex Transm Dis"},{"issue":"4","key":"e_1_2_13_39_1","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1097\/OLQ.0000000000000942","article-title":"High Interest in doxycycline for sexually transmitted infection postexposure prophylaxis in a multicity survey of men who have sex with men using a social networking application","volume":"46","author":"Spinelli MA","year":"2019","journal-title":"Sex Transm Dis"},{"issue":"7","key":"e_1_2_13_40_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/OLQ.0b013e31820e64fd","article-title":"Chemoprophylaxis is likely to be acceptable and could mitigate syphilis epidemics among populations of gay men","volume":"38","author":"Wilson DP","year":"2011","journal-title":"Sex Transm Dis"},{"issue":"12","key":"e_1_2_13_41_1","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/cid\/ciz1236","article-title":"Has pre\u2010exposure prophylaxis made a difference at a population level? Jury is still out","volume":"71","author":"Marcus JL","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"9","key":"e_1_2_13_42_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/OLQ.0000000000001395","article-title":"Interest, concerns, and attitudes among men who have sex with men and health care providers toward prophylactic use of doxycycline against chlamydia trachomatis infections and syphilis","volume":"48","author":"Park JJ","year":"2021","journal-title":"Sex Transm Dis"},{"issue":"5","key":"e_1_2_13_43_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/OLQ.0000000000001769","article-title":"Predominance of high\u2010level tetracycline\u2010resistant Neisseria gonorrhoeae in Kenya: implications for global implementation of doxycycline postexposure prophylaxis for prevention of sexually transmitted infections","volume":"50","author":"Soge OO","year":"2023","journal-title":"Sex Transm Dis"},{"issue":"11","key":"e_1_2_13_44_1","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1128\/JCM.01236-09","article-title":"First Neisseria gonorrhoeae genotyping analysis in France: identification of a strain cluster with reduced susceptibility to ceftriaxone","volume":"47","author":"Monfort L","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"12","key":"e_1_2_13_45_1","article-title":"Syphilis as re\u2010emerging disease, antibiotic resistance, and vulnerable population: global systematic review and meta\u2010analysis","volume":"11","author":"Orbe\u2010Orihuela YC","year":"2022","journal-title":"Pathogens"},{"issue":"5","key":"e_1_2_13_46_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1517\/14740338.7.5.571","article-title":"The use and safety of doxycycline hyclate and other second\u2010generation tetracyclines","volume":"7","author":"Sloan B","year":"2008","journal-title":"Expert Opin Drug Saf"},{"issue":"2","key":"e_1_2_13_47_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000458761","article-title":"Phototoxicity of doxycycline: a systematic review on clinical manifestations, frequency, cofactors, and prevention","volume":"30","author":"Goetze S","year":"2017","journal-title":"Skin Pharmacol Physiol"},{"issue":"11","key":"e_1_2_13_48_1","first-page":"701","article-title":"Safety of longer\u2010term doxycycline use: a systematic review and meta\u2010analysis with implications for bacterial sexually transmitted infection chemoprophylaxis","volume":"50","author":"Chan PA","year":"2023","journal-title":"Sex Transm Dis"},{"key":"e_1_2_13_49_1","doi-asserted-by":"crossref","first-page":"e303","DOI":"10.1111\/jdv.20280","article-title":"Doxycycline\u2010induced fixed drug eruption: the new epidemic?","volume":"39","author":"Brehon A","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_13_50_1","volume-title":"Sexually Transmitted Infections Treatment Guidelines","year":"2021"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:48:36Z","timestamp":1748260116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.20387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jdv.20387"],"URL":"https:\/\/doi.org\/10.1111\/jdv.20387","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}