{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:24:43Z","timestamp":1791915883933,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic, inflammatory, neutrophilic skin disease associated with a considerable clinical burden. In more severe disease, subepidermal draining tunnels may form.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the clinical profile of patients with moderate\u2013severe HS with and without draining tunnels, and the clinical and health\u2010related quality of life (HR\u2010QoL) burden of draining tunnels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from the Adelphi HS Disease Specific Programme\u2122, a cross\u2010sectional survey with retrospective data collection, across the United States, France, Germany, Italy, Spain and the United Kingdom between November 2020 and April 2021. Patients were aged \u226510\u2009years and had HS. Clinical outcomes, recorded by physicians, comprised patient demographics and HS characteristics, symptoms and treatment. HR\u2010QoL measures included patient and physician survey questions, and validated HR\u2010QoL instruments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 580 patients with moderate\u2013severe HS, 46% had draining tunnels. Patients with draining tunnels had more abscesses, inflammatory nodules and scarring than those without. Patients with draining tunnels were significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) more likely to be treated with biologics (41% vs. 27%), but often patients with tunnels who were eligible for biologics had not received them. Patients with draining tunnels experienced significantly more inflammation\/redness (73% vs. 63%), drainage from lesions (62% vs. 40%) and pain on sitting (48% vs. 37%) than those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Draining tunnels were also significantly associated with low mood\/depression (30% vs. 18%), sleep disturbance (28% vs. 19%) and fatigue (28% vs. 18%) versus no tunnels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Physicians agreed that patients with draining tunnels experienced a negative impact of disease compared to those without. This was reflected in patient\u2010reported surveys and HR\u2010QoL instruments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with moderate\u2013severe HS and draining tunnels experience greater clinical and HR\u2010QoL burden than those without, emphasizing the importance of tunnels in disease impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20550","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T12:16:43Z","timestamp":1738671403000},"page":"1431-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hidradenitis suppurativa with and without draining tunnels: A real\u2010world study characterizing differences in treatment and disease burden"],"prefix":"10.1111","volume":"39","author":[{"given":"J. R.","family":"Ingram","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity Cardiff University, University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-4169","authenticated-orcid":false,"given":"A. V.","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Prens","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-6845","authenticated-orcid":false,"given":"S.","family":"Schneider\u2010Burrus","sequence":"additional","affiliation":[{"name":"Center for Dermatosurgery  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Warren","sequence":"additional","affiliation":[{"name":"Dermatology Centre Northern Care Alliance NHS Foundation Trust  Manchester UK"},{"name":"NIHR Manchester Biomedical Research Centre Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Keal","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jha","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim Am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Hernandez Daly","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim Am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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