{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:59:52Z","timestamp":1782953992607,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is essential to identify individuals with the highest risk of developing melanoma and to withhold individuals from surveillance with a low risk. However, international consensus on surveillance indications and the role of family history is still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To provide more insight into the association between a family history of melanoma and the risk of developing melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults who participated in the surveillance programme of the University Medical Center Groningen between June 1995 and November 2017 were retrospectively included. Participants were stratified into risk groups according to genetic assessment and family history following current Dutch guidelines: hereditary melanoma (risk group 1), familial melanoma (risk group 2) and their first\u2010degree relatives (risk group 3), and other screening reasons (risk group 0). We included individuals fulfilling the \u2018possible familial melanoma\u2019 criteria (risk group 4) and their first\u2010degree relatives (risk group 5), as evolving Dutch guidelines no longer recommend to screen these individuals. Melanoma incidence during follow\u2010up was compared with the general population using standardized incidence ratios (SIRs), and the rate of developing melanomas was compared between risk groups and expressed as adjusted hazard ratios (aHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 224 participants were included (mean age 44.7\u2009years; 56.7% female). During a median follow\u2010up of 5.6\u2009years (IQR, 3.7\u20137.8), a total number of 61 melanomas were diagnosed among 38 (17.0%) participants. The overall melanoma risk was significantly higher than in the general population (SIR 73). The rate of developing melanoma in risk group 4 was comparable to risk group 2 (aHR 1.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.576).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stratification of individuals according to their family history of melanoma identifies those with a high risk of developing melanoma. Contrary to Dutch recommendations, surveillance should also be considered for melanoma patients fulfilling the \u2018possible familial melanoma\u2019 criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20601","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:17:32Z","timestamp":1741738652000},"page":"1903-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying high\u2010risk melanoma patients: The importance of acquiring a detailed family history"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-2267","authenticated-orcid":false,"given":"M. R.","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El Moumni","sequence":"additional","affiliation":[{"name":"Department of Traumasurgery University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. L.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"van den Akker","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr128"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31559-9"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.999"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0494"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.12.894"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00185.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0795-351"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103150"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.016"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.044"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000915)87:6<809::AID-IJC8>3.0.CO;2-U"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.05.005"},{"key":"e_1_2_14_14_1","unstructured":"Melanoma Genetics Consortium (GenoMEL).Familial melanoma.2024Available from:https:\/\/genomel.org\/familial\u2010melanoma\/[Accessed 18 September 2024]."},{"key":"e_1_2_14_15_1","unstructured":"S3\u2010Leitlinie zur Diagnostik Therapie und Nachsorge des Melanoms. Leitlinienprogramm Onkologie.2020. Available from:https:\/\/www.leitlinienprogramm\u2010onkologie.de\/fileadmin\/user_upload\/Downloads\/Leitlinien\/Melanom\/Melanom_Version_3\/LL_Melanom_Langversion_3.3.pdf[Accessed 18 September 2024]."},{"key":"e_1_2_14_16_1","unstructured":"Erfelijke en familiaire melanomen: richtlijnen voor diagnostiek en preventie.Stichting Opsporing Erfelijke Tumoren (STOET).2021Available from:https:\/\/vkgn.stoet.nl\/index.php?article_id=28[Accessed 18 September 2024]"},{"key":"e_1_2_14_17_1","unstructured":"Richtlijn melanoom. Federatie Medisch Specialisten (FMS).2013. 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