{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:06:23Z","timestamp":1790366783202,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Photodynamic therapy (PDT) is a recognized treatment for superficial basal cell carcinoma (sBCC). Conventional PDT (C\u2010PDT) has a relatively high clearance rate but is time\u2010consuming and painful. Simulated daylight PDT (SDL\u2010PDT) has the potential advantage of causing less pain, but its effectiveness has not been investigated thoroughly.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To determine whether SDL\u2010PDT is non\u2010inferior to C\u2010PDT in the treatment of clinically diagnosed sBCC and to assess adverse events during treatment and patient preferences.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this single\u2010centre, non\u2010inferiority, randomized controlled trial, adult patients with sBCCs of any size and located on anatomical sites suitable for PDT were recruited. Lesions were randomized to two sessions of either SDL\u2010PDT or C\u2010PDT using aminolevulinic acid as the photosensitizer. Patient\u2010perceived pain was measured using a numeric rating scale (NRS) ranging from 0 to 10. Self\u2010report forms were used to measure patient preferences. Patients were evaluated after 3\u2009months to assess early treatment failure and after 1\u2009year to determine overall clearance rates.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 78 participants with 193 sBCCs were treated. Most lesions (47.2%) were located on the trunk and were diagnosed solely through dermoscopic evaluation (64.2%). After 1\u2009year, the clearance rate was 62.4% for SDL\u2010PDT and 91.8% for C\u2010PDT (\n p<\/jats:italic>\n \u2009<\u20090.001) disproving non\u2010inferiority. Illumination was reported to be more painful during C\u2010PDT (mean NRS score of 3.5 at session 1 and 3.7 at session 2) compared with SDL\u2010PDT (mean NRS score of 0.1 at both sessions) (\n p<\/jats:italic>\n \u2009<\u20090.001). Immediately after treatment, 87.5% of respondents expressed a preference for SDL\u2010PDT.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n SDL\u2010PDT is less effective than C\u2010PDT but is also less painful. Due to the lower clearance rate, this study does not support SDL\u2010PDT as a primary treatment option for sBCC. The randomized controlled trial was registered at\n http:\/\/www.researchweb.org\/<\/jats:ext-link>\n (project 264721).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.20602","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T04:53:42Z","timestamp":1739854422000},"page":"1997-2004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simulated daylight vs. conventional\n PDT<\/scp>\n for clinical superficial\n BCC<\/scp>\n : A randomized controlled trial"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-9291","authenticated-orcid":false,"given":"Alexandra","family":"Sj\u00f6holm","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-5644","authenticated-orcid":false,"given":"Eva","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Modin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5557","authenticated-orcid":false,"given":"Julia","family":"Fougelberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-323X","authenticated-orcid":false,"given":"Magdalena","family":"Claeson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-8535","authenticated-orcid":false,"given":"John","family":"Paoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113254"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.006"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17309"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16017"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15796"},{"key":"e_1_2_14_7_1","article-title":"Interventions for basal cell carcinoma of the skin","volume":"11","author":"Thomson J","year":"2020","journal-title":"Cochrane Database Syst 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