{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:17:50Z","timestamp":1790741870585,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phase III clinical trials are designed to evaluate the therapeutic effect of drugs and their superiority over other treatment methods, but biologics for hidradenitis suppurativa (HS) have not been compared head\u2010to\u2010head in phase III studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the relative efficacy and safety of biologics for HS in a network meta\u2010analysis including available data from phase III trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEDLINE and Embase were searched for phase III trials investigating the efficacy and\/or safety of at least one biologic for moderate\u2010to\u2010severe HS. The odds ratios for reaching an HS Clinical Response 50 (HiSCR50) and for the occurrence of adverse events after 12\u201316\u2009weeks were compared between treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PIONEER I and II (adalimumab 40\u2009mg weekly vs. placebo), SUNSHINE and SUNRISE (secukinumab 300\u2009mg every 2 vs. 4\u2009weeks vs. placebo) as well as BE HEARD I and II (bimekizumab 320\u2009mg every 2 vs. 4\u2009weeks vs. placebo) with 2731 patients were included. Adalimumab weekly was ranked most effective in reaching a HiSCR50 with significant superiority over secukinumab every 2\u2009weeks (OR\u2009=\u20091.74; 95% confidence interval [CI]: 1.11\u20132.73) and 4\u2009weeks (OR\u2009=\u20091.72; 95% CI: 1.09\u20132.7) and insignificant superiority over bimekizumab every 2\u2009weeks (OR\u2009=\u20091.23; 95% CI: 0.74\u20132.06) and 4\u2009weeks (OR\u2009=\u20091.25; 95% CI: 0.73\u20132.14). Adalimumab showed the fewest adverse events with significant superiority over bimekizumab every 2\u2009weeks (OR\u2009=\u20090.52; 95% CI: 0.32\u20130.86) and insignificant superiority over bimekizumab every 4\u2009weeks (OR\u2009=\u20090.79; 95% CI: 0.47\u20131.33) and secukinumab every 2\u2009weeks (OR\u2009=\u20090.69; 95% CI: 0.45\u20131.07) and 4\u2009weeks (OR\u2009=\u20090.71; 95% CI: 0.46\u20131.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among currently approved biologic agents for moderate\u2010to\u2010severe HS, adalimumab demonstrated the highest efficacy and safety in the first 12\u201316\u2009weeks of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20617","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:48:14Z","timestamp":1741693694000},"page":"637-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy and safety of biologics for hidradenitis suppurativa: A network meta\u2010analysis of phase III trials"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-2336","authenticated-orcid":false,"given":"Laura","family":"Calabrese","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"},{"name":"Institute of Dermatology Catholic University of the Sacred Heart  Rome Italy"},{"name":"Department of Dermatology and Allergy University Hospital, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-1486","authenticated-orcid":false,"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, LMU  Munich Germany"},{"name":"Department of Dermatology, Thalkirchner Street Hospital Munich Municipial Hospital Group  Munich Germany"},{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous 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