{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:03:58Z","timestamp":1785927838562,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early\u2010stage mycosis fungoides (MF) is often an indolent disease with a favourable prognosis, though 25% progress to advanced stages. Patients with \u226510% body surface area (BSA) involvement have a worse prognosis than those with &lt;10%, but the impact of other BSA levels remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine whether additional BSA cut\u2010off points higher than 10% provide additional prognostic information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 401 patients with early\u2010stage MF of the Leiden University Medical Centre and a validation cohort of 602 patients from the PROCLIPI database. Different percentages of lesional BSA were analysed both in the total groups and in subgroups of patients with only patch\u2010stage disease or with patch\u2013plaques\u2010stage disease, and correlated with survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both cohorts showed a progressive and gradual decline in overall survival (OS) with each 10% increase in BSA, reaching a 5\u2010year OS below 50% (LUMC) or 70% (PROCLIPI) for BSA \u226540%. In both cohorts, patients with a BSA of 10%\u201339% had a significantly worse OS than those with a BSA of less than 10%, but a significantly better OS than those with \u226540%. These differences in OS were only found in patients with patches and plaques and not in patients with only patches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An additional cut\u2010off point of 40% involved BSA has prognostic significance in patients with early patch\/plaque\u2010stage MF and may be included in future updates of the clinical staging system. In these patients, systemic therapies should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20773","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T09:00:17Z","timestamp":1748509217000},"page":"116-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognosis of increasing percentages of lesional body surface area in early stage mycosis fungoides"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3142-9656","authenticated-orcid":false,"given":"Juliette M.","family":"Kersten","sequence":"first","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-4322","authenticated-orcid":false,"given":"Rosanne","family":"Ottevanger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen D.","family":"Quint","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-4613","authenticated-orcid":false,"given":"Maarten H.","family":"Vermeer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle J.","family":"Goeman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University Medical Centre  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Evison","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Service University Hospital Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia J.","family":"Scarisbrick","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Service University Hospital Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-7616","authenticated-orcid":false,"given":"Rein","family":"Willemze","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2018.002"},{"issue":"4","key":"e_1_2_13_4_1","first-page":"504","article-title":"Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients","volume":"136","author":"Doorn R","year":"2000","journal-title":"Arch Dermatol"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.7665"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27627"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13939"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12403"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17258"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.712"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26760"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1057894"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70491-3"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18852"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1597"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.009"},{"key":"e_1_2_13_19_1","unstructured":"National Comprehensive Cancer Network.NCCN clinical practice guidelines in oncology (NCCN guidelines) primary cutaneous lymphomas. 2022. Available from:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/primary_cutaneous.pdf(Last accessed 14 March 2025)."},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar5894"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19252"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:07:34Z","timestamp":1766484454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.20773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jdv.20773"],"URL":"https:\/\/doi.org\/10.1111\/jdv.20773","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"2024-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}