{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:12:45Z","timestamp":1790993565488,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo (non\u2010segmental) is a chronic autoimmune skin disease leading to white patches. Although vitiligo has been delineated previously, the endophenotypes of the disease are still to be defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate, without prior hypotheses, whether different clinical phenotypes of vitiligo could be identified and differ based on their demographic and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, non\u2010interventional, single\u2010centre study included patients with vitiligo. Demographic and clinical characteristics of vitiligo were recorded. Hierarchical cluster analysis was then performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 399 patients were included. The cluster analysis classified the patients into five clusters as follows: (1) \u2018highly active patients\u2019 with elevated frequency of disease activity signs, receiving combinatorial topical and systemic therapy; (2) mild vitiligo patients with younger patients, low surface area involved and absence of signs of disease activity; (3) extensive vitiligo patients, with older patients and the largest surface area involved; (4) and (5) mild or moderate to severe disease, with localization of the lesions on site of chronic skin friction (type 2A koebner phenomenon).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with vitiligo can be classified into five phenotypes, with two defining the highly active and extensive patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.20785","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T03:05:32Z","timestamp":1749438332000},"page":"670-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters"],"prefix":"10.1111","volume":"40","author":[{"given":"Laura","family":"Galissi","sequence":"first","affiliation":[{"name":"CHU de Bordeaux, Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, H\u00f4pital Saint\u2010Andr\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Beno\u00eet","sequence":"additional","affiliation":[{"name":"SciLicium  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ribal","family":"Merhi","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, H\u00f4pital Saint\u2010Andr\u00e9  Bordeaux France"},{"name":"Univ. Bordeaux, CNRS, ImmunoConcEpT  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Drullion","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, ImmunoConcEpT  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Andreu","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, H\u00f4pital Saint\u2010Andr\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-4589","authenticated-orcid":false,"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henri Mondor University Hospital  Cr\u00e9teil France"},{"name":"EA 7379 EpidermE, Faculty of Medicine Universit\u00e9 Paris\u2010Est Cr\u00e9teil, UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Darde","sequence":"additional","affiliation":[{"name":"SciLicium  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-1222","authenticated-orcid":false,"given":"Katia","family":"Boniface","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, ImmunoConcEpT  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-0908","authenticated-orcid":false,"given":"Julien","family":"Seneschal","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Disorders, H\u00f4pital Saint\u2010Andr\u00e9  Bordeaux France"},{"name":"Univ. Bordeaux, CNRS, ImmunoConcEpT  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00026-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8622-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118828"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19451"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19450"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.040"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.11.032"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18950"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12065"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00838.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4483"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12561"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.20785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.20785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:37:37Z","timestamp":1776868657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.20785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jdv.20785"],"URL":"https:\/\/doi.org\/10.1111\/jdv.20785","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}