{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:54:34Z","timestamp":1792547674130,"version":"4.5.0"},"reference-count":98,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There has been a recent shift in the epidemiology of superficial fungal infections (tinea, dermatophytosis, dermatomycoses).\n                    <jats:italic>Trichophyton indotineae<\/jats:italic>\n                    is an emerging dermatophyte species of significant global concern for its contagious nature and antifungal drug resistance. This scoping review includes available clinical and laboratory assessments of\n                    <jats:italic>T.\u2009indotineae<\/jats:italic>\n                    to provide a comprehensive up\u2010to\u2010date overview of its epidemiology, clinical manifestations, diagnostic approaches, antifungal susceptibility patterns, resistance mechanisms and management strategies. We discuss\n                    <jats:italic>T.\u2009indotineae<\/jats:italic>\n                    resistance against standard and newer antifungals (terbinafine, griseofulvin and triazoles including fluconazole, itraconazole, voriconazole and posaconazole). In particular, the terbinafine susceptibility profile of\n                    <jats:italic>T.\u2009indotineae<\/jats:italic>\n                    can be linked to squalene epoxidase (\n                    <jats:italic>SQLE<\/jats:italic>\n                    ) single\u2010nucleotide variations. For diagnosis, it is not possible to separate\n                    <jats:italic>T.\u2009indotinea<\/jats:italic>\n                    e from other members of the\n                    <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\n                    complex (\n                    <jats:italic>T.\u2009mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>T.\u2009interdigitale<\/jats:italic>\n                    ) without access to molecular diagnostic methods. So, in patients presenting with extensive dermatophytoses, with a history of treatment resistance and\/or recent travel, molecular diagnosis to confirm\n                    <jats:italic>T.\u2009indotineae<\/jats:italic>\n                    infection should be considered. Healthcare providers often face challenges in choosing between terbinafine and itraconazole treatments. While the use of terbinafine is limited due to resistance, itraconazole is hindered by erratic absorption, possible drug interactions and side effects as well as resistance in some cases. Newer treatments being investigated include super\u2010bioavailable itraconazole, third\u2010generation triazoles (voriconazole, posaconazole) and topical\u2010oral combination regimens. The need for improved diagnostic accessibility, judicious antifungal prescribing, and implementing an effective antifungal stewardship program are highlighted.\n                  <\/jats:p>","DOI":"10.1111\/jdv.20810","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:48:57Z","timestamp":1751608137000},"page":"29-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<i>Trichophyton indotineae<\/i>\n                    : Epidemiology, antifungal resistance and antifungal stewardship strategies"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Mediprobe Research Inc  London Ontario 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