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This guideline offers advice on the diagnosis, investigation, treatment and follow\u2010up for the management of epididymo\u2010orchitis. For treatment of patients with a history suggestive of sexually transmitted pathogens\u2014ceftriaxone dose increased to 1\u2009g intramuscularly (IM) single dose alongside doxycycline. The use of dual therapy with azithromycin is no longer recommended, unless cefixime is being given as an alternative to ceftriaxone. For treatment of patients with a history including risks for both sexually transmitted and enteric pathogens\u2014ceftriaxone IM single dose and either ofloxacin or levofloxacin is recommended. Where enteric pathogens are suspected as the likely cause, either ofloxacin or levofloxacin is recommended as monotherapy. 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