{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:20:21Z","timestamp":1788970821966,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016434","name":"Moxie Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic spontaneous urticaria (CSU), a disease predominantly affecting females, has limited information available on its differences between females and males of varying ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate sex differences in age groups regarding disease activity, comorbidities, quality of life (QoL) and treatment patterns in CSU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed Chronic Urticaria Registry (CURE) data, an international real\u2010world registry for patients with chronic urticaria. Patients were recruited via an online platform using a standardized questionnaire. The data were analysed for demographics, age of onset, duration of urticaria, (Urticaria Activity Score [UAS], Urticaria Control Test [UCT], Chronic Urticaria Quality of Life Questionnaire [CU\u2010Q2oL]), family history, systemic symptoms, aggravating factors, comorbidities, smoking and alcohol consumption, laboratory parameters, burden of disease, treatment distribution and response rates, compliance to treatment and adverse events. Comparisons were made among age groups &lt;13, 13\u201317, 18\u201330, 31\u201350, 51\u201365 and &gt;65\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across 4136 CSU patients (from 58 sites across 29 countries), 2994 (72.4%) were female. Statistically significant female predominance started at age 31 (&lt;0.001). Compared with males, females showed higher rates of angioedema (59.6 vs. 51.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), systemic symptoms (34.6 vs. 25.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), sleep disturbance (38.9 vs. 32.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), QoL impairment (CU\u2010Q2oL score 32 vs. 27.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower rates of urticaria control than males in all medication categories (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all). Females had more concomitant diseases, including asthma, thyroid disease, obesity, autoimmune disease, gastrointestinal disease and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all). The disease was especially more burdensome and refractory in females aged 51\u201365\u2009years than males, evidenced by more angioedema and systemic symptoms, worse QoL, lower UCT scores and more emergency visits (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all). However, these differences were not prominent in the elderly females (&gt;65\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with males, female CSU patients experience more burdensome disease, which gets worse in midlife.<\/jats:p>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      (or equivalent) listing (if applicable None).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70027","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:39:38Z","timestamp":1758199178000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sex matters in\n                    <scp>CSU<\/scp>\n                    : Women face greater burden and poorer urticaria control, especially in midlife\u2014\n                    <scp>CURE<\/scp>\n                    insights"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2801-0959","authenticated-orcid":false,"given":"Emek","family":"Kocat\u00fcrk","sequence":"first","affiliation":[{"name":"Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology  Berlin Germany"},{"name":"Department of Dermatology Bah\u00e7e\u015fehir University School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Salameh","sequence":"additional","affiliation":[{"name":"Institute of Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology  Berlin Germany"},{"name":"Gilbert and Rose\u2010Marie Chagoury School of Medicine Lebanese American University  Beirut Lebanon"},{"name":"Department of Primary Care and Population Health University of Nicosia Medical School  Nicosia Cyprus"},{"name":"Faculty of Pharmacy Lebanese University  Hadat 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Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"},{"name":"Department of Pulmonology Astana Medical University  Astana Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kovalkova","sequence":"additional","affiliation":[{"name":"Moscow Research and Clinical Center of Allergy and Immunology, Moscow Healthcare Department City Clinical Hospital  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-4720","authenticated-orcid":false,"given":"Marina","family":"Lebedkina","sequence":"additional","affiliation":[{"name":"Moscow Research and Clinical Center of Allergy and Immunology, Moscow Healthcare Department City Clinical Hospital  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Kasperska\u2010Zajac","sequence":"additional","affiliation":[{"name":"European Center for Diagnosis and Treatment of Urticaria\/Angioedema (GA2LEN UCARE\/ACARE Network), Department of Clinical Allergology and Urticaria Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"European Center for Diagnosis and Treatment of Urticaria\/Angioedema (GA2LEN UCARE\/ACARE Network), Department of Clinical Allergology and Urticaria Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Zam\u0142y\u0144ski","sequence":"additional","affiliation":[{"name":"European Center for Diagnosis and Treatment of Urticaria\/Angioedema (GA2LEN UCARE\/ACARE Network), Department of Clinical Allergology and Urticaria Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokvalai","family":"Kulthanan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papapit","family":"Tuchinda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khoshkhui","sequence":"additional","affiliation":[{"name":"Allergy Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Hassanpour","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, School of Medicine Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonny","family":"Peter","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, University of Cape Town, Allergy and Immunology Unit University of Cape Town Lung Institute  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-1977","authenticated-orcid":false,"given":"Aurelie","family":"Du\u2010Thanh","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Meshkova","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology Smolensk State Medical University  Smolensk Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abuzakouk","sequence":"additional","affiliation":[{"name":"Department of Allergy &amp; Immunology, MSI Cleveland Clinic  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makris","sequence":"additional","affiliation":[{"name":"Allergy Unit \u201cD. 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