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Factors associated with drug survival were identified using Kaplan\u2013Meier curves and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 406 patients were included, 58.1% received MTX per os (MTX\u2010PO) and 41.9% subcutaneously (MTX\u2010SC). At MTX initiation, the median PASI score was 11, and 67.3% had DLQI \u22656. Adjusted drug survival did not statistically differ according to the route of administration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Limited number of patients leading to a potential lack of power. Residual confounding cannot be waived due to the observational nature of the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall MTX survival did not significantly differ according to the route of administration. However, with MTX\u2010SC, the hazard of discontinuation for ineffectiveness was lower and of discontinuation for intolerance was higher than with MTX\u2010PO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70044","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:39:19Z","timestamp":1759217959000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of methotrexate administration route on drug survival in psoriasis: Results from\n                    <scp>PSOBIOTEQ<\/scp>"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6818-2012","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Paris","sequence":"first","affiliation":[{"name":"Dermatologie HCL, H\u00f4pital Edouard Herriot  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00eblle","family":"Curmin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Gouillon","sequence":"additional","affiliation":[{"name":"Dermatologie HCL, H\u00f4pital Edouard Herriot  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Giboin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"De Rycke","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re D\u00e9partement de Sant\u00e9 Publique, Centre de Pharmaco\u00e9pid\u00e9miologie (Cephepi)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Bachelez","sequence":"additional","affiliation":[{"name":"Dermatologie AP\u2010HP, H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Beneton","sequence":"additional","affiliation":[{"name":"Dermatologie CHU Le Mans  Le Mans 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