{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:44:16Z","timestamp":1793234656945,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is an autoimmune condition leading to hair loss. Baricitinib, a Janus kinase (JAK) inhibitor, has demonstrated efficacy in controlled clinical trials, but real\u2010world data on its long\u2010term effectiveness and safety remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the real\u2010life effectiveness and safety of baricitinib 4\u2009mg daily in Italian adult patients with severe AA over a 48\u2010week treatment period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a 48\u2010week retrospective, observational, multicenter study across 27 Italian university hospitals. Adult patients (18\u201365\u2009years) with severe AA (Severity of Alopecia Tool [SALT] score\u2009\u2265\u200950) who initiated baricitinib 4\u2009mg daily treatment between November 2022 and October 2023 were included. Effectiveness was measured by the percentage of patients achieving SALT \u226420 at week 48. Secondary outcomes included changes in mean SALT score, trichoscopic findings, patient\u2010reported quality of life (Skindex\u201016, Hospital Anxiety and Depression Scale [HADS]), and Clinician\u2010Reported Outcomes (ClinRO) for eyebrows and eyelashes. Adverse events were also documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 253 patients (66.8% females, mean age 40.0\u2009\u00b1\u200912.6\u2009years) were included. By week 48, 63.2% achieved SALT \u226420, and 75.5% achieved SALT \u226430. The mean SALT score significantly decreased from 93.7\u2009\u00b1\u200914.1 at baseline to 26.5\u2009\u00b1\u200933.0 at week 48 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Trichoscopic assessment showed a decline in yellow dots (97.6%\u201350.2%), black dots (43.5%\u20139.1%), and dystrophic hairs (14.6%\u20134.3%), whilst regrowing hairs increased (7.1%\u201380.2%). Skindex\u201016 scores improved significantly (57.1\u2009\u00b1\u200925.0 to 30.0\u2009\u00b1\u200917.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as did HADS Anxiety (8.21\u2009\u00b1\u20099.38 to 4.62\u2009\u00b1\u20094.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and HADS Depression (6.36\u2009\u00b1\u20094.55 to 3.70\u2009\u00b1\u20094.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adverse events were reported in 9.4% of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real\u2010world study confirms the effectiveness of baricitinib in achieving significant hair regrowth and improving psychological well\u2010being in severe AA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70067","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:41:13Z","timestamp":1758627673000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effectiveness and safety of baricitinib in severe alopecia areata: 48\u2010week results"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-9689","authenticated-orcid":false,"given":"Bianca Maria","family":"Piraccini","sequence":"first","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-7864","authenticated-orcid":false,"given":"Stephano","family":"Cedirian","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-767X","authenticated-orcid":false,"given":"Francesca","family":"Pampaloni","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-941X","authenticated-orcid":false,"given":"Luca","family":"Rapparini","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Quadrelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-425X","authenticated-orcid":false,"given":"Francesca","family":"Bruni","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ala","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Science \u2013 Dermatology Section Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Acri","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Science \u2013 Dermatology Section Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-3423","authenticated-orcid":false,"given":"Alfredo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Science \u2013 Dermatology Section Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Science \u2013 Dermatology Section Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-2060","authenticated-orcid":false,"given":"Francesco","family":"Lacarrubba","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Dall'Oglio","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Micali","sequence":"additional","affiliation":[{"name":"Chair, Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6646-9864","authenticated-orcid":false,"given":"Luciano","family":"Foggia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Cantelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nappa","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-9052","authenticated-orcid":false,"given":"Laura","family":"Diluvio","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naldi","family":"Luigi","sequence":"additional","affiliation":[{"name":"Dermatology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bolzon","sequence":"additional","affiliation":[{"name":"Dermatology Unit San Bortolo Hospital  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Translational Medicine and Surgery Catholic University of the S. 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Dermatological Unit, DISCLIMO Polytechnic Marche University  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8052-9324","authenticated-orcid":false,"given":"Edoardo","family":"de Simoni","sequence":"additional","affiliation":[{"name":"Dermatological Unit, DISCLIMO Polytechnic Marche University  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-7003","authenticated-orcid":false,"given":"Francesca","family":"Ambrogio","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe\u2010J) University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Boccaletti","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fragh\u00ec","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-4169","authenticated-orcid":false,"given":"Angelo Valerio","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alessandra","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-2434","authenticated-orcid":false,"given":"Andrea","family":"Sechi","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6479-0986","authenticated-orcid":false,"given":"Luca","family":"Valtellini","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Barbareschi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Gallo","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-9586","authenticated-orcid":false,"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isotta Giunipero","family":"Di Corteranzo","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medical Sciences University of Turin  Turin 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 L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Science, Dermatology Section University of Siena, S. 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Maria Alle Scotte Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-1999","authenticated-orcid":false,"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-9357","authenticated-orcid":false,"given":"Flavia","family":"Manzo Margiotta","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa 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