{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:07:41Z","timestamp":1783429661673,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Three conventional systemic treatments, acitretin, methotrexate and cyclosporine, are used for severe childhood psoriasis. In many countries, they are the only treatments available. There are limited data and no comparative evaluations of these treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The international, multicentre, retrospective, real\u2010world\n                      <jats:styled-content style=\"fixed-case\">ACMe<\/jats:styled-content>\n                      cohort was developed to assess the comparative 2\u2010year drug survival of acitretin, methotrexate and cyclosporine in paediatric psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty dermatology centres in France, Italy, Portugal, Canada and the\n                      <jats:styled-content style=\"fixed-case\">United Kingdom<\/jats:styled-content>\n                      participated in the study. Demographic and clinical data were collected using a standardized form for patients receiving treatment from 2014 to 2024.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 506 patients received 683 treatments: acitretin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009316), methotrexate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009245) and cyclosporine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009122). Median drug survival at 2\u2009years was similar for acitretin (10.8\u2009months) and methotrexate (10.9\u2009months), but lower for cyclosporine (3.9\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The most common reasons for discontinuation were inefficacy for cyclosporine (43.0%), and loss of effectiveness for acitretin (27.2%) and methotrexate (31.8%). No demographic, clinical or therapeutic characteristics were associated with higher rates of treatment maintenance at 6 months. Drug survival was higher for acitretin when used as a first\u2010line therapy (median drug survival: 11.3\u2009months for first\u2010line vs. 5.5\u2009months for second\u2010 or subsequent\u2010line therapy;\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001), but there were no differences for methotrexate and cyclosporine. Adverse events (AEs) were the reason for stopping treatment in 13.8% of patients on acitretin, 23.1% on methotrexate and 14.0% on cyclosporine (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.02). Only one serious AE was reported: hepatitis in the methotrexate group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This cohort study showed that acitretin and methotrexate had comparable 2\u2010year drug survival rates, which were superior to cyclosporine. We did not find any predictive factors for increased treatment maintenance except for first\u2010line use of acitretin.\n                      <jats:styled-content style=\"fixed-case\">AEs<\/jats:styled-content>\n                      were a frequent reason for discontinuing treatments. These results may help develop treatment algorithms for systemic therapy in paediatric psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70108","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:09:42Z","timestamp":1760702982000},"page":"250-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Drug survival of systemic treatments for severe paediatric psoriasis: An international retrospective study"],"prefix":"10.1111","volume":"40","author":[{"given":"Yunyun","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Victor Dupouy Groupement Hospitalier de Territoire Sud Val d'Oise \u2010 Nord Hauts\u2010de\u2010Seine  Argenteuil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Department of Public Health Centre Hospitalier Universitaire Raymond Poincar\u00e9, Assistance Publique\u2010H\u00f4pitaux de Paris  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Piram","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, CHU Sainte\u2010Justine Research Center Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess","family":"McPherson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oxford University Hospitals NHS Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-0870","authenticated-orcid":false,"given":"Tiago","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centro Acad\u00e9mico Cl\u00ednico, ICBAS\/Santo Ant\u00f3nio University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Yesli","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, CHU Sainte\u2010Justine Research Center Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-9900","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4tel\u2010Dieu Centre Hospitalier Universitaire de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bodemer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology, Centre Hospitalier Universitaire Necker\u2010Enfants Malades Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Arcispedale Santa Maria Nuova Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Tardieu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology Centre Hospitalier Universitaire Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hubiche","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Archet 2  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertille","family":"Bonniaud","sequence":"additional","affiliation":[{"name":"Departement of Dermatology, H\u00f4pital Le Bocage Centre Hospitalier R\u00e9gional Universitaire de Dijon  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Neri","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCSS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Adriano","family":"Chessa","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCSS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-4027","authenticated-orcid":false,"given":"Audrey","family":"Lasek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Saint Vincent de Paul Universit\u00e9 Catholique de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-2045","authenticated-orcid":false,"given":"Francesca","family":"Prignano","sequence":"additional","affiliation":[{"name":"Dermatology Section, Department of Health Science University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-9100","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Barbarot","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4tel\u2010Dieu Centre Hospitalier Universitaire de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Claire","family":"Bursztejn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre Hospitalier R\u00e9gional Universitaire de Nancy H\u00f4pitaux de Brabois  Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Leducq","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Unit of Pediatric Dermatology University of Tours and Nantes, INSERM 1246 SPHERE, Centre Hospitalier R\u00e9gional Universitaire de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Sergeant","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre Hospitalier R\u00e9gional Universitaire de Nancy H\u00f4pitaux de Brabois  Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Puzenat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier R\u00e9gional Universitaire de Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-5409","authenticated-orcid":false,"given":"Christine","family":"Chiaverini","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital Archet 2  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Sigg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Universitaire d'Angers  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Mallet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre Hospitalier Universitaire de la Timone H\u00f4pitaux Universitaires de Marseille \u2013 Assistance Publique\u2010H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dermatology Centre Hospitalier Universitaire de St\u2010Pierre  Saint\u2010Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Pourchot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Poissy\u2010Saint\u2010Germain\u2010en\u2010Laye  Saint\u2010Germain\u2010en\u2010Laye France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinari Xina","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology, St John's Institute of Dermatology Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-2836","authenticated-orcid":false,"given":"Esther","family":"Burden\u2010Teh","sequence":"additional","affiliation":[{"name":"Centre of Evidence Based Dermatology, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-6286","authenticated-orcid":false,"given":"Carsten","family":"Flohr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology, St John's Institute of Dermatology Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Di Lernia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Arcispedale Santa Maria Nuova Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-1827","authenticated-orcid":false,"given":"Emmanuel","family":"Mah\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Victor Dupouy Groupement Hospitalier de Territoire Sud Val d'Oise \u2010 Nord Hauts\u2010de\u2010Seine  Argenteuil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GrPso of the Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie; Groupe de Recherche de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie P\u00e9diatrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09593.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.07.029"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14507"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1078"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13507"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.049"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1911641"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-015-0137-1"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2020.01.021"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13936"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00758-2"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4835"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12940"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.1000"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1088131"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13713"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.3029"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2625"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2019.03.007"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.996515"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2013.01.001"},{"key":"e_1_2_13_24_1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1001\/archderm.137.11.1532","article-title":"Cyclosporine in childhood psoriasis","volume":"137","author":"Mah\u00e9 E","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1120852"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01079-8"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3763"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14326"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15327"},{"key":"e_1_2_13_30_1","first-page":"45","article-title":"Optimal management of plaque psoriasis in adolescents: current perspectives","volume":"10","author":"Mah\u00e9 E","year":"2020","journal-title":"Psoriasis (Auckl)"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2019.07.005"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljac128"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:21:49Z","timestamp":1770834109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jdv.70108"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70108","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}