{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:17:19Z","timestamp":1778933839084,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pruritus may accompany different skin diseases including atopic dermatitis, lichen planus, psoriasis, cutaneous lupus erythematosus, acne, alopecia areata and rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate the expression of pruritus\u2010associated genes in the above\u2010mentioned seven skin diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the Gene Expression Omnibus database and retrieved microarray data sets for the respective skin diseases. We searched the Gene Set Enrichment Analysis\u2013Molecular Signatures database to obtain the pruritus\u2010associated gene set. We examined the expression of the pruritus\u2010associated genes in the microarray data sets to identify the differentially expressed genes compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We retrieved 147 pruritus\u2010associated genes from the Gene Set Enrichment Analysis\u2010Molecular Signatures database and analysed their expression in nine data sets, representing seven skin diseases and totalling biopsies collected from 80 healthy individuals and 208 lesional skin. We found the top differentially upregulated pruritus\u2010associated genes were\n                      <jats:italic>CLEC7A<\/jats:italic>\n                      ,\n                      <jats:italic>IL7R<\/jats:italic>\n                      and\n                      <jats:italic>TNFRSF1B<\/jats:italic>\n                      in acne;\n                      <jats:italic>HLA\u2010DRA<\/jats:italic>\n                      ,\n                      <jats:italic>IL2RG<\/jats:italic>\n                      and\n                      <jats:italic>POU2AF1<\/jats:italic>\n                      in alopecia areata;\n                      <jats:italic>IL2RG<\/jats:italic>\n                      ,\n                      <jats:italic>PLEC<\/jats:italic>\n                      and\n                      <jats:italic>CTLA4<\/jats:italic>\n                      in atopic dermatitis;\n                      <jats:italic>CLEC7A<\/jats:italic>\n                      ,\n                      <jats:italic>IL7R<\/jats:italic>\n                      and\n                      <jats:italic>LIPA<\/jats:italic>\n                      in cutaneous lupus erythematosus;\n                      <jats:italic>HLA\u2010DRA<\/jats:italic>\n                      ,\n                      <jats:italic>ABCA12<\/jats:italic>\n                      and\n                      <jats:italic>IL7R<\/jats:italic>\n                      in lichen planus;\n                      <jats:italic>CLEC7A<\/jats:italic>\n                      ,\n                      <jats:italic>TGM1<\/jats:italic>\n                      and\n                      <jats:italic>SDR9C7<\/jats:italic>\n                      in psoriasis and\n                      <jats:italic>IL7R<\/jats:italic>\n                      ,\n                      <jats:italic>HLA\u2010DRB1\/HLA\u2010DRB3\/HLA\u2010DRB4\/HLA\u2010DRB5<\/jats:italic>\n                      \/LOC105369230 and\n                      <jats:italic>POU2AF1<\/jats:italic>\n                      in rosacea.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While some genes are shared among these diseases, others are unique to each condition. Our findings emphasize the complexity of itch pathogenesis and highlight the importance of personalized treatment for each patient. It also lays the groundwork for studying pruritus\u2010associated genes on a genomic level to identify the therapeutic targets tailored to each disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70109","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:54:15Z","timestamp":1760406855000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The expression of pruritus\u2010associated genes in seven skin diseases: Evidence from microarray"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-760X","authenticated-orcid":false,"given":"Manahel Mahmood","family":"Alsabbagh","sequence":"first","affiliation":[{"name":"Princess Al\u2010Jawhara Center for Molecular Medicine and Inherited Disorders and Department of Molecular Medicine, College of Medicine and Medical Sciences Arabian Gulf University  Manama Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae260"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.076"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.644760"},{"issue":"2","key":"e_1_2_12_5_1","first-page":"147","article-title":"Lichen planus: a descriptive study of 242 patients","volume":"16","author":"Al Chalabi QS","year":"2021","journal-title":"Rev Latinoam Hipertens"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2563"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000948"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3491798"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211016098"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123997"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02828.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2022.11.004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2022.9408"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad381"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484354"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.4899"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.04.018"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20851"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.09.002"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01418.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06804-y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2287"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6966"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.04.021"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12543"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-013-1102-0"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.03.017"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150326"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1303611"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.08.009"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48856-1"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130675"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0166-2"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03755-5"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080321"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129956"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.08.042"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.015"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:55:19Z","timestamp":1773032119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jdv.70109"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70109","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}