{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:56:19Z","timestamp":1784541379472,"version":"3.55.0"},"reference-count":197,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rosacea is a chronic, inflammatory dermatosis driven by a complex interplay of genetic, environmental and lifestyle factors, collectively known as the exposome. This review explores how intrinsic contributors such as genetic susceptibility, immune dysregulation, microbiome alterations, hormonal influences and psychosocial stress intersect with extrinsic triggers like ultraviolet radiation (UVR), air pollution, dietary factors, and climate variability to shape rosacea pathogenesis. Recent advances in single\u2010cell transcriptomics have identified fibroblasts as key components of inflammatory and vascular pathways in rosacea. Concurrently, discoveries in non\u2010coding RNAs and RNA modifications reveal subtype\u2010specific molecular signatures and novel biomarkers. Mendelian randomization (MR) studies further reveal causal links between rosacea and autoimmune, metabolic and gastrointestinal comorbidities\u2014that rosacea is more than skin deep. The role of the gut\u2013skin axis, particularly involving small intestinal bacterial overgrowth (SIBO) and\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, reflects the importance of microbial and neuroimmune crosstalk. Disparities in diagnosis and management persist, particularly among individuals with skin of colour (SOC) and those with limited healthcare access. By integrating an exposomal framework, this review advocates for a paradigm shift in rosacea management: from reactive treatment to proactive, exposome\u2010informed intervention. Personalized skincare, microbiome\u2010targeted strategies, dietary modulation and psychosocial support represent emerging pillars in a holistic, precision medicine framework. Future research should prioritize exposome\u2010informed prevention, inclusive care models, and the development of personalized interventiouns that address both cutaneous and systemic facets of rosacea.\n                  <\/jats:p>","DOI":"10.1111\/jdv.70112","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:55:06Z","timestamp":1760406906000},"page":"387-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The exposomal imprint on rosacea: More than skin deep"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-1928","authenticated-orcid":false,"given":"Katerina","family":"Grafanaki","sequence":"first","affiliation":[{"name":"Department of Dermatology\u2010Venereology, School of Medicine University of Patras  Patras Greece"},{"name":"Department of Biochemistry, School of Medicine University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Bakoli Sgourou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Maniatis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathia","family":"Pasmatzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Venereology, School of Medicine University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506630"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15122"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02279-y"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osae001"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr236"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00680-z"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062180"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11010011"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00595-7"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.351"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.24.15258"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.9.3086"},{"key":"e_1_2_15_14_1","first-page":"323","article-title":"Cutaneous and ocular rosacea: common and specific physiopathogenic mechanisms and study models","volume":"27","author":"Rodrigues\u2010Braz D","year":"2021","journal-title":"Mol Vis"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.02.745"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.4728"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30951"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871528113666140522104422"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-018-0675-z"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb11926.x"},{"key":"e_1_2_15_22_1","first-page":"7","article-title":"Recent advances in understanding and managing rosacea","author":"Buddenkotte J","year":"2018","journal-title":"F1000Research"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.001"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.222"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52946-7"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S356551"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10662.x"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1029818"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42073-6"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13765"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16498"},{"key":"e_1_2_15_32_1","article-title":"The impact of smoking and alcohol consumption on rosacea: a multivariable mendelian randomization study. Front","volume":"12","author":"Chu Z","year":"2024","journal-title":"Public Health"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1353823"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16392"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-04142-w"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13796"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.113"},{"issue":"8","key":"e_1_2_15_38_1","first-page":"2153","article-title":"Exploring the pathogenesis and mechanism\u2010targeted treatments of rosacea: previous understanding and updates","volume":"11","author":"Chen C","year":"2023","journal-title":"Biomedicine"},{"issue":"10","key":"e_1_2_15_39_1","article-title":"Evaluation of helicobacter pylori and small intestinal bacterial overgrowth in subjects with rosacea","volume":"16","author":"Nelson JM","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2230"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.53"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.11.004"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.055"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13501"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00220.x"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy184"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.016"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00753.x"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00665.x"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39761-2"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9705950"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.12.005"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23310"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19732"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.01.023"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15301"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.5070\/D32010024262"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18201"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14816"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10174.x"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7021"},{"issue":"2","key":"e_1_2_15_62_1","article-title":"Analysis and characterization of the facial skin microbiota in rosacea. Jundishapur","volume":"16","author":"Li J","year":"2023","journal-title":"J Microbiol"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01635-6"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00460-1"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00458-9"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(11)70088-6"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12121"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2012.10.592"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2023.33410"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14098"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03433-y"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01624-x"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614559262"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03472.x"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.054"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16183149"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.003"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00964-6"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.09.013"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14930"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9390-z"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091562"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14020"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08958.x"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00557-5"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.07.063"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13542"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03392-4"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.10.029"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16499"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.032"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16417"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14689"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14556"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1092781"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2748"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3668"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1576"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-03982-w"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v103.6485"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1155\/drp\/5532532"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0106-9"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506627"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.659171"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.09.002"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.005"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16596"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15339"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13616"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.08.436"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.09.002"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.3.243"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.01.092"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.03.010"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00286.x"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12455"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12367"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/applmicrobiol4020066"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13837"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70627"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2014.00011"},{"issue":"6","key":"e_1_2_15_125_1","first-page":"742","article-title":"Prognostic significance of ischemic mitral regurgitation after non\u2010Q\u2010wave acute myocardial infarction","volume":"14","author":"Perez de Isla L","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12030"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae291"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16614"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.09.008"},{"issue":"6","key":"e_1_2_15_130_1","first-page":"1025","article-title":"Occupational skin disease","volume":"66","author":"Peate WE","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.126"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2021.05.009"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13310"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16492"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.09.045"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12881"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12524458"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204405"},{"issue":"12","key":"e_1_2_15_139_1","first-page":"49","article-title":"Rosacea and diet: what is new in 2021?","volume":"14","author":"Searle T","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2021.10.004"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030411"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14771"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14483"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.040"},{"issue":"2","key":"e_1_2_15_145_1","first-page":"110","article-title":"Is the effect of smoking on rosacea still somewhat of a mystery?","volume":"35","author":"Kucukunal A","year":"2016","journal-title":"Cutan Ocul Toxicol"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03802.x"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3442"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231078"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02095-w"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14178"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010115"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S134857"},{"issue":"9","key":"e_1_2_15_153_1","first-page":"SF3595563","article-title":"Supplement article: skin barrier deficiency in rosacea: an algorithm integrating OTC skincare products into treatment regimens","volume":"21","author":"Baldwin H","year":"2022","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7010"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5861"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.6838"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.08.002"},{"key":"e_1_2_15_158_1","article-title":"Associations of polysocial risk score with incident rosacea: a prospective cohort study of government employees in China. Front","volume":"11","author":"Chen P","year":"2023","journal-title":"Public Health"},{"issue":"1","key":"e_1_2_15_159_1","first-page":"41","article-title":"Healthcare utilization and costs of patients with rosacea in an insured population","volume":"7","author":"Romanowicz M","year":"2008","journal-title":"J Drugs Dermatol"},{"issue":"12","key":"e_1_2_15_160_1","first-page":"S14","article-title":"Diagnosing and treating rosacea in skin of color patients","volume":"16","author":"Sangha AM","year":"2023","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5925"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2024.05.008"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3272052381"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad307"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S126850"},{"issue":"4","key":"e_1_2_15_166_1","article-title":"Interventions for rosacea","volume":"2015","author":"Zuuren EJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065849"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13408"},{"issue":"6","key":"e_1_2_15_170_1","first-page":"306","article-title":"Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double\u2010blind, vehicle\u2010controlled study","volume":"92","author":"Draelos ZD","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14849"},{"issue":"3","key":"e_1_2_15_172_1","first-page":"37","article-title":"Azelaic acid topical formulations: differentiation of 15% gel and 15% foam","volume":"10","author":"Del Rosso JQ","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.034"},{"issue":"3","key":"e_1_2_15_174_1","first-page":"316","article-title":"Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double\u2010blind, vehicle\u2010controlled pivotal studies","volume":"13","author":"Stein L","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00461-0"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.063"},{"issue":"6","key":"e_1_2_15_177_1","first-page":"650","article-title":"Efficacy and safety of once\u2010daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double\u2010blind, and vehicle\u2010controlled pivotal studies","volume":"12","author":"Fowler J","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10716.x"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17590"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18420"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S412800"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13041126"},{"issue":"2","key":"e_1_2_15_183_1","first-page":"97","article-title":"Standard management options for rosacea, part 2: options according to subtype","volume":"84","author":"Odom R","year":"2009","journal-title":"Cutis"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23176"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2021.11.001"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12124000"},{"issue":"2","key":"e_1_2_15_187_1","first-page":"97","article-title":"Patient preferences and therapeutic satisfaction with topical agents for rosacea: a survey\u2010based study","volume":"11","author":"Williamson T","year":"2018","journal-title":"Am Health Drug Benefits"},{"key":"e_1_2_15_188_1","unstructured":"Effects of oral supplement containing L\u2010histidine and antioxidants on the skin barrier function and systemic inflammation in rosacea [ongoing study]. Integrative Skin Science and Research.2023Updated 2024 Aug 27. Available from:https:\/\/clinicaltrials.gov\/study\/NCT06072066. [Accessed 21 September 2025]"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2025.2463093"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01201-24"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.13043"},{"issue":"3","key":"e_1_2_15_192_1","article-title":"Efficacy of low\u2010dose isotretinoin in the treatment of rosacea: a systematic review and meta\u2010analysis","volume":"16","author":"Assiri A","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754241253195"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2024.04.009"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20552"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70249"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223251339964"},{"issue":"3","key":"e_1_2_15_198_1","article-title":"Ivermectin: a multifaceted drug with a potential beyond anti\u2010parasitic therapy","volume":"16","author":"Kaur B","year":"2024","journal-title":"Cureus"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:54:58Z","timestamp":1773032098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":197,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jdv.70112"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70112","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}