{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:15:59Z","timestamp":1789150559992,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a chronic inflammatory skin disorder that often precedes psoriatic arthritis. Conflicting evidence exists regarding whether biologic therapies for psoriasis can prevent or delay psoriatic arthritis onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether biologic therapy for psoriasis is associated with a reduced incidence of psoriatic arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was performed utilizing Optum's de\u2010identified Clinformatics\u00ae Data Mart Database, from January 1, 2007, to February 29, 2024. Patients with moderate\u2010to\u2010severe psoriasis were identified by phototherapy use. Among these, some continued on phototherapy, and others switched to a biologic. Individuals with a psoriatic arthritis diagnosis or history of biologic therapy prior to phototherapy initiation were excluded. Cases of psoriatic arthritis developing within 1\u2009year after biologic initiation were also excluded to minimize protopathic bias. Outcomes included the incidence of psoriatic arthritis, measured as incident cases per 1000 person\u2010years. Hazard ratios (HRs) for psoriatic arthritis development were calculated using a multivariable Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 36,508 patients who received phototherapy for psoriasis, 26,470 met eligibility criteria. Among these, 2611 patients switched to biologics, while 23,859 patients did not. The overall PsA incidence rate was 7.85 per 1000 person\u2010years. Patients continuing phototherapy alone had an incidence rate of 8.06 per 1000 person\u2010years, compared with 6.75 in the biologic cohort. After multivariable adjustment for demographics, comorbidities, insurance type and oral systemic therapy, biologic use was associated with a lower likelihood of psoriatic arthritis development compared with phototherapy (adjusted HR, 0.66; 95% CI, 0.53\u20130.83;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study of moderate\u2010to\u2010severe psoriasis patients, those who initiated biologic therapy demonstrated a lower incidence of psoriatic arthritis than those continuing on phototherapy alone. This suggests that biologic treatments may delay or prevent psoriatic arthritis in psoriasis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70167","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:40:21Z","timestamp":1762436421000},"page":"900-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of biologic use on the development of psoriatic arthritis: A population\u2010based study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1368-1167","authenticated-orcid":false,"given":"Kathleen L.","family":"Miao","sequence":"first","affiliation":[{"name":"Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Guo","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khristina","family":"Lung","sequence":"additional","affiliation":[{"name":"Keck\u2010Schaeffer Initiative for Population Health Policy Keck School of Medicine of University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-8707","authenticated-orcid":false,"given":"April W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine David Geffen School of Medicine at the University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.023"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.027"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39494"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.057"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2023.05.010"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010219961"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/8thj0l"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010220865"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41946"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010220761"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103682"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.09.019"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-024-00680-3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae257"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010021\u201000706\u2010y"},{"key":"e_1_2_12_20_1","unstructured":"Optum's de\u2010identified Clinformatics\u00ae Data Mart Database. 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