{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:19:08Z","timestamp":1788218348098,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2690"],"award-info":[{"award-number":["FOR 2690"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 5211"],"award-info":[{"award-number":["FOR 5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, the management of chronic prurigo (CPG; prurigo nodularis) relies on expert consensus and guidelines without providing detailed recommendations on long\u2010term treatment management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was initiated by an expert committee to define, validate and reach consensus on treat\u2010to\u2010target (T2T) criteria and a decision\u2010supporting treatment algorithm for CPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, single\u2010centre, non\u2010interventional study was conducted in adult CPG patients at a moderate\u2010to\u2010severe disease stage, experiencing intense itch (NRS \u22657; Group A), and in patients who considered themselves successfully treated (Group B). The patients answered questions about their most severe symptoms and essential therapy goals. A committee of 14 field experts evaluated the study results, identified outcome tools from clinical trials and defined and weighted T2T criteria. Based on this, a treatment algorithm was developed through an iterative consensus\u2010building method and anonymous voting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      171 patients (Group A,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200996; Group B,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975) were interviewed. Itch (99.4%), the need to scratch (48%), and pruriginous lesions (45.6%) were the most frequently reported severe symptoms. Pruritus relief (over complete pruritus resolution) and healing of lesions were the key therapeutic goals. In clinical trials, the most frequently used instruments were assessments of worst\/peak itch intensity, disease severity via IGA, DLQI and sleep quality. According to the results, the experts defined initial itch control as NRS \u22643, lesion healing with IGA\u2010S 0\/1, and burden, along with their respective clinically measurable parameters, as T2T criteria. These criteria, with predefined cut\u2010off values, serve as the decision\u2010tree keys that constitute the treatment algorithm presented here, facilitating a decision to maintain or switch the treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The T2T criteria and the SWITCH treatment algorithm offer a valid and systematic method for evaluating and refining CPG treatment based on patient\u2010reported and expert\u2010validated data. This will help to improve the treatment of patients with CPG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70171","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:47:26Z","timestamp":1762598846000},"page":"1185-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The\n                    <scp>SWITCH<\/scp>\n                    algorithm: An expert consensus on treat\u2010to\u2010target criteria for chronic prurigo"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1886-1294","authenticated-orcid":false,"given":"Lea S.","family":"Stahl","sequence":"first","affiliation":[{"name":"Section Pruritus Medicine, Department of Dermatology, and Center of Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-8627","authenticated-orcid":false,"given":"Claudia","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Section Pruritus Medicine, Department of Dermatology, and Center of Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6247-8997","authenticated-orcid":false,"given":"Joyce","family":"Loewenthal","sequence":"additional","affiliation":[{"name":"Section Pruritus Medicine, Department of Dermatology, and Center of Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-959X","authenticated-orcid":false,"given":"Svenja","family":"Royeck","sequence":"additional","affiliation":[{"name":"Section Pruritus Medicine, Department of Dermatology, and Center of Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"Competence Center of Healthcare Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-6587","authenticated-orcid":false,"given":"Robert","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"Innovaderm Research  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-5020","authenticated-orcid":false,"given":"Sarina","family":"Elmariah","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-7161","authenticated-orcid":false,"given":"Brian S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-7059","authenticated-orcid":false,"given":"Laurent","family":"Misery","sequence":"additional","affiliation":[{"name":"Laboratoire Interactions Neurones\u2010Keratinocytes (LINK) University of Brest  Brest France"},{"name":"Department of Dermatology and Venereology University Hospital of Brest  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-1377","authenticated-orcid":false,"given":"Hiroyuki","family":"Murota","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-6711","authenticated-orcid":false,"given":"Hong Liang","family":"Tey","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Center  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-0224","authenticated-orcid":false,"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Division of Occupational Dermatology, Department of Dermatology University of Heidelberg  Heidelberg 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