{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:03:31Z","timestamp":1788390211347,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Male sex appears to be associated with more advanced melanoma stage and inferior prognosis, but population\u2010based data on sex disparities in stage\u2010specific recurrence and mortality remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to examine sex disparities in (1) melanoma stage at diagnosis and (2) stage\u2010specific recurrence and long\u2010term melanoma\u2010specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This population\u2010based cohort study included all Danes with melanoma from 2004 to 2022 identified in the Danish Cancer Register. The impact of sex on melanoma stage diagnosis (Breslow thickness, presence of ulceration, presence of lymph node metastases and presence of distant metastases) was investigated using multivariable logistic regression models. Furthermore, we examined melanoma recurrence, melanoma\u2010specific and overall mortality for stage I\u2009+\u2009II (localized), stage III (locoregional) and stage IV (metastatic) melanoma in a competing risk model, adjusting for stage at diagnosis, comorbidity, age and calendar year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 30,497 individuals diagnosed with melanoma; the median follow\u2010up time was 8\u2009years, and 14,409 (47%) were male. Males had, compared to females, an increased adjusted odds ratio (aOR) of Breslow thickness &gt;4\u2009mm (aOR 1.45, 95% CI: 1.31\u20131.59), presence of ulceration (aOR 1.28, 1.18\u20131.39), &gt;1 lymph node metastases (aOR: 1.58, 1.38\u20131.80) and distant metastases (aOR: 1.69, 1.48\u20131.94). In stage\u2010adjusted analyses, males with localized melanoma had an increased adjusted hazard ratio (aHR) of melanoma recurrence (aHR: 1.38, 1.27\u20131.51) and melanoma\u2010specific mortality (aHR: 1.51, 1.34\u20131.71). In patients with locoregional and metastatic melanoma, males had an inferior prognosis, but it was less pronounced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide cohort study found that males were more likely to be diagnosed with more advanced stages of melanoma. Analyses stratified by stage at diagnosis, showed that males had a 20%\u201350% higher risk of melanoma recurrence, melanoma\u2010specific and overall mortality across localized, locoregional and metastatic melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70180","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:20:29Z","timestamp":1763986829000},"page":"1515-1524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sex disparities in melanoma stage, recurrence and mortality: A\u00a0Danish cohort study, 2004 to 2024"],"prefix":"10.1111","volume":"40","author":[{"given":"J. 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