{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:39:11Z","timestamp":1788586751757,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is associated with a significant psychological burden, particularly an increased risk of major depressive disorder (MDD). Janus kinase (JAK) inhibitors are emerging as an effective treatment for AA, yet their impact on MDD risk remains unclear. Understanding this association could inform treatment decisions and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine if treatment with JAK inhibitors is associated with a reduced incidence of MDD in AA patients compared to those receiving other treatments or no treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized the TriNetX international healthcare database, including patients diagnosed with AA between 1 January 2011 and 30 June 2024. Patients were categorized into two groups based on JAK inhibitor use within 6 months after AA diagnosis. Propensity score matching ensured balanced groups across observed covariates. The primary outcome was MDD diagnosis between 6\u2009months and 5\u2009years after AA diagnosis. Secondary outcomes included new antidepressant prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 1838 patients in each group (conventional treatments with or without JAK inhibitors) were analysed. Treatment with JAK inhibitors was significantly associated with a lower risk of MDD [aHR: 0.42, 95% confidence interval (CI): 0.22\u20130.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009] and antidepressant prescriptions (aHR: 0.46, 95% CI: 0.32\u20130.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). These findings were consistent across 1\u2010year, 3\u2010year, 5\u2010year and 10\u2010year periods. Subgroup analyses revealed stronger associations in younger patients (18\u201329\u2009years), those of White ethnicity, and those treated at academic medical centres.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that JAK inhibitor treatment in AA patients is associated with a significantly lower incidence of MDD and reduced antidepressant use. These findings suggest a potential role for JAK inhibitor in improving mental health in AA. Randomized controlled trials are warranted to confirm these findings and explore the long\u2010term safety and benefits of JAK inhibitors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70184","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T11:35:16Z","timestamp":1763206516000},"page":"1382-1391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Janus kinase inhibitors with reduced depression in alopecia areata"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1046-0959","authenticated-orcid":false,"given":"Chih\u2010Yi","family":"Ho","sequence":"first","affiliation":[{"name":"Department of General Medicine Shuang Ho Hospital, Taipei Medical University  New\u00a0Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-4509","authenticated-orcid":false,"given":"Ying\u2010Xiu","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Dermatology Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-7064","authenticated-orcid":false,"given":"Yi\u2010Hsien","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shuang Ho Hospital, Taipei Medical University  New\u00a0Taipei City Taiwan"},{"name":"Department of Dermatology, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Hsuan","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shuang Ho Hospital, Taipei Medical University  New\u00a0Taipei City Taiwan"},{"name":"Department of Anesthesiology, School of Medicine, College of Medicine Taipei Medical University  Taipei 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