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Despite their widespread impact on quality of life\u2014including stigmatization, anxiety and depression\u2014comprehensive, unified and practical clinical guidelines are lacking. This global consensus project convened 10 leading dermatologists and pigmentary disorder experts from Africa, Asia, Europe and the Americas to develop an evidence\u2010based, internationally applicable framework for the management of common MHD, including melasma, post\u2010inflammatory hyperpigmentation, acquired dermal macular hyperpigmentation, periorbital hyperpigmentation, chronic hyperpigmentary photodamage, freckles\/ephelides and hyperpigmentation of the folds. Based on a comprehensive literature review and a structured Delphi process, the expert panel formulated consensus statements and tailored treatment algorithms that account for skin type, photobiological behaviour, disease severity and regional access to therapies. Special emphasis was placed on the role of broad\u2010spectrum photoprotection and the challenges of tinted sunscreen availability in diverse populations. Treatment options ranged from topical lightening agents and systemic therapies (e.g. oral tranexamic acid) to procedural interventions (e.g. chemical peels, lasers and IPL) stratified by disease subtype and pigmentation depth. Notably, the consensus highlights that effective MHD management must address not only melanocytes but also the surrounding skin microenvironment, including fibroblasts, mast cells and vascular components. This consensus provides a globally adaptable clinical guide for the diagnosis and management of MHD, emphasizing a personalized approach that bridges scientific rigour with real\u2010world applicability across diverse populations and health systems.<\/jats:p>","DOI":"10.1111\/jdv.70185","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:34:25Z","timestamp":1765265665000},"page":"760-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Global consensus on the management of melanin hyperpigmentation disorders"],"prefix":"10.1111","volume":"40","author":[{"given":"Thierry","family":"Passeron","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seemal R.","family":"Desai","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Innovative Dermatology  Plano Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Al\u2010Niaimi","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital Aalborg University  Aalborg Denmark"},{"name":"Taktouk Clinic  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ncoza","family":"Dlova","sequence":"additional","affiliation":[{"name":"University of Kwa\u2010Zulu Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl E.","family":"Grimes","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-0031","authenticated-orcid":false,"given":"Jorge","family":"Ocampo\u2010Candiani","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-4879","authenticated-orcid":false,"given":"Rashmi","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Lady Hardinge Medical College, Part of the Delhi University  New Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-3962","authenticated-orcid":false,"given":"Leihong Flora","family":"Xiang","sequence":"additional","affiliation":[{"name":"Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"Helio Amante","family":"Miot","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina UNESP  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llaf381"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.12.065"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.01.051"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1309557"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.03.067"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12048"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.09.025"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962013000100009"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16614"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12986"},{"key":"e_1_2_13_12_1","article-title":"Dermatology: how to manage facial hyperpigmentation in skin of colour. 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