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Excess weight increases susceptibility to psoriasis and is associated with more severe disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the impact of weight\u2010loss interventions on psoriasis severity (Psoriasis Area and Severity Index [PASI], PASI50, PASI75, PASI100 [50%\/75%\/100% reduction in baseline PASI, respectively]) and quality of life (Dermatology Life Quality Index [DLQI]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched five databases and two trial registries (inception to 03\/09\/2025). Outcomes were informed by patient focus\u2010group discussions. Randomized controlled trials (RCTs) in adults with psoriasis, comparing any weight\u2010loss intervention versus usual care or a lower\u2010intensity weight\u2010loss intervention, were included. Studies had to report a change in weight and\u2009\u22651 psoriasis severity or quality\u2010of\u2010life measure. Random effects meta\u2010analyses were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen RCTs (1145 participants) with 14 comparisons were included. Eleven interventions advised dietary changes, of which four included physical activity. Three used weight\u2010loss medications. Across 14 comparisons (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091145, mean difference (MD) in weight change: \u22126.7\u2009kg), weight\u2010loss interventions produced a greater reduction in PASI versus control: MD \u22122.5 (95%CI: \u22123.8 to \u22121.1,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200985.2%). We found a significant effect of weight\u2010loss interventions on the likelihood of achieving PASI75 (RR\u2009=\u20091.6, 95%CI: 1.1\u20132.2,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200922.6% [based on six comparisons,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009681, MD in weight change: \u22127.3\u2009kg]). There was no statistically significant effect of the interventions on the likelihood of achieving PASI50 (RR\u2009=\u20091.5, 95%CI: 0.9\u20132.4,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200972.8% [based on four comparisons,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009509, MD in weight change: \u22124.0\u2009kg]) or PASI100 (RR\u2009=\u20091.6, 95%CI: 0.3\u20139.7,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0% [based on two comparisons,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009334, MD in weight change: \u22125.2\u2009kg]), but both analyses were limited by few studies. Across seven comparisons (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009364; MD in weight change \u22127.8\u2009kg), weight\u2010loss interventions were associated with a significant improvement in DLQI compared to control: MD \u22125.0 (95%CI: \u22129.7 to \u22120.3,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200996.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010certainty evidence suggests weight\u2010loss interventions can improve psoriasis severity and quality of life, and should be considered as part of routine treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70247","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:55:37Z","timestamp":1766138137000},"page":"980-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of weight\u2010loss interventions on psoriasis severity: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Sarah","family":"Morrow","sequence":"first","affiliation":[{"name":"University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poppy","family":"Hawkins","sequence":"additional","affiliation":[{"name":"University of Hertfordshire  Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E. 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