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The Psoriasis Research Group of the French Society of Dermatology has developed new guidelines to provide updated decision\u2010making algorithms for the systemic treatment of adult patients with moderate\u2010to\u2010severe psoriasis. The algorithms were created following a thorough review of existing psoriasis treatment guidelines and recent publications on new systemic therapies not included in previous recommendations. They propose updated treatment strategies that combine established and emerging systemic therapies for patients with plaque psoriasis and psoriatic arthritis. The working group recommends methotrexate, adalimumab or ustekinumab as the primary systemic treatment for patients with psoriasis without symptomatic comorbidities. 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