{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:49:38Z","timestamp":1783633778234,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009754","name":"Galderma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prurigo nodularis (PN) is a neuroimmune skin disease characterized by the presence of chronic itch (\u22656\u2009weeks) and multiple white\u2010pink papules, nodules and\/or plaques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The OLYMPIA long\u2010term extension (OLYMPIA\u2010LTE) trial evaluates long\u2010term, over 184\u2009weeks, safety and efficacy of nemolizumab in adults with moderate\u2010to\u2010severe PN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with moderate\u2010to\u2010severe PN, who completed phase 2b (NCT03181503) and phase 3 (OLYMPIA 1&amp;2) lead\u2010in trials, were eligible for the ongoing OLYMPIA\u2010LTE trial. Patients receiving nemolizumab monotherapy (continuous\u2010nemolizumab) during lead\u2010in trials continued their regimen, while those on placebo (nemolizumab\u2010na\u00efve) initiated nemolizumab monotherapy. The primary endpoint was long\u2010term safety. Efficacy assessments included the proportion of patients achieving a \u22654\u2010point improvement from baseline Peak Pruritus Numerical Rating Scale (PP\u2010NRS4), Sleep Disturbance Numerical Rating Scale (SD\u2010NRS4) and Dermatology Life Quality Index (DLQI4) scores, Investigator's Global Assessment (IGA) score 0\/1 (clear\/almost clear), and 75% healed pruriginous lesions (Prurigo Activity and Severity score item\u20105b). Observed cases up to week 100, regardless of rescue medication, are presented, without imputation of missing data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At interim analysis data cut\u2010off (21 July 2024), 290\/508 (57%) patients completed week 100 (median exposure: 839.5\u2009days). Treatment\u2010emergent adverse events (TEAEs) occurred in 89% of patients (452\/508; exposure time\u2010adjusted incidence rate: 197.5\/100 patient\u2010years) and were mostly mild\/moderate (26%\/52%) in severity. TEAEs occurring in \u22655% of patients at any given year were COVID\u201019 (28%), nasopharyngitis (20%), upper respiratory tract infection (13%), neurodermatitis (worsening of PN; 13%), back pain (9%), headache (9%), arthralgia (9%), cough (8%), hypertension (8%) and nummular eczema (8%). At week 100, among evaluable patients treated with nemolizumab, 92% achieved PP\u2010NRS4, 86% SD\u2010NRS4, 91% DLQI4, 74% IGA 0\/1 and 84% observed healing of &gt;75% of pruriginous lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term treatment with nemolizumab was well tolerated and led to disease control with clinically meaningful improvements in itch intensity, pruriginous lesions and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration No<\/jats:title>\n                    <jats:p>NCT04204616, RD.06.SPR.202699 and 2019\u2010004294\u201013 (EudraCT Number).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70266","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:41:36Z","timestamp":1765975296000},"page":"1195-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nemolizumab in prurigo nodularis up to 100\u2009weeks:\n                    <scp>OLYMPIA LTE<\/scp>\n                    interim analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-4739","authenticated-orcid":false,"given":"Franz J.","family":"Legat","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn G.","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Maryland Itch Center 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of Dermatology, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-9100","authenticated-orcid":false,"given":"Sebastien","family":"Barbarot","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine Wroc\u0142aw University of Science and Technology  Wroc\u0142aw Poland"},{"name":"Cityclinic: Medical and Psychological Center  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-3440","authenticated-orcid":false,"given":"Curdin","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Dermatology Lausanne 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