{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:57:56Z","timestamp":1789041476899,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Objectives<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease characterized by intense itch that affects approximately 20% of children and up to 10% of adults. Our systematic review aims to identify biomarkers with clinical significance for predicting response to systemic therapies and treatment\u2010related adverse events (AEs) for AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted across the electronic databases Embase and MEDLINE from database inception to September 2024. All records were independently screened at both the title\/abstract and full\u2010text stages. Included articles were randomized controlled trials, cohort studies or case\u2013control studies that reported relevant data for investigating associations between biomarkers and disease progression and\/or change in disease activity over time. All discrepancies at any stage were resolved through adjudication by a senior reviewer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 28 papers evaluating biomarkers for treatment response and 11 for AEs. Across treatment response studies, biomarkers investigated included IgE, eosinophils, LDH, TARC, cytokines, genetic variants and the skin microbiome. Most studies investigated the association between biomarkers and dupilumab, while studies reporting associations between biomarkers and AEs were limited to dupilumab\u2010related conjunctivitis and ocular surface disease (DAOSD). The primary findings on treatment response were inconsistent, demonstrating that while elevated LDH was associated with poorer response to dupilumab, neither IgE nor eosinophil count showed consistent predictive value. Regarding the association between biomarkers and AEs, IgE was identified as the most promising predictor of DAOSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predicting therapeutic responses and identifying patients at risk of developing AEs will be increasingly important with an expanding range of treatment options for AD. Finding robust predictive biomarkers for AD, however, is complicated by its clinical heterogeneity and multifactorial aetiology. Collaborative projects, such as BIOMAP, hold great potential to advance precision medicine and enhance individualized care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70330","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:50:55Z","timestamp":1769881855000},"page":"1173-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers for therapeutic response and adverse outcomes in atopic dermatitis: A systematic review"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8163-823X","authenticated-orcid":false,"given":"Eva","family":"Hilger","sequence":"first","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Chan","sequence":"additional","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphonsus","family":"Yip","sequence":"additional","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue Maria","family":"Wang","sequence":"additional","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-5000","authenticated-orcid":false,"given":"Conor","family":"Broderick","sequence":"additional","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Arents","sequence":"additional","affiliation":[{"name":"Dutch Association for People with Atopic Dermatitis  Nijkerk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"van Bart","sequence":"additional","affiliation":[{"name":"Royal College of Physicians National Guideline Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-2674","authenticated-orcid":false,"given":"Kilian","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, School of Medicine Technical University of Munich  Munich Germany"},{"name":"Division of Dermatology and Venerology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rastrick","sequence":"additional","affiliation":[{"name":"Immunology Research New Medicines UCB Pharma  Slough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-6286","authenticated-orcid":false,"given":"Carsten","family":"Flohr","sequence":"additional","affiliation":[{"name":"Unit for Paediatric and Population\u2010Based Dermatology Research, School of Basic and Medical Biosciences, St John's Institute of Dermatology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BIOMAP Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19580"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18636"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010022\u201000499\u2010x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.01.019"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1028694"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15578"},{"key":"e_1_2_14_8_1","unstructured":"BroderickC LewisS vanBartK ArentsB GulhaneL RastrickJ et\u00a0al.A systematic review of biomarkers that predict responses to systemic therapies in atopic dermatitis.2020. PROSPERO;https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=193265"},{"key":"e_1_2_14_9_1","unstructured":"BroderickC LewisS vanBartK GulhaneL ArentsB RastrickJ et\u00a0al.A systematic review of biomarkers that predict adverse reactions to systemic therapies in atopic dermatitis. PROSPERO;https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=193274"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.01.021"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462312000086"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010144\u20106\u2010200603210\u201000010"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14080"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2193663"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.4476"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030791"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206575"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062189"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae321"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18109"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2310643"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12234"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061982"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201002950\u20104"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.003"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100317"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.06.022"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14267"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15609"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19911"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2008.29.3160"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.043"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.12.052"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.3014"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.4639"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1227420"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1160710"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.05.029"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad032"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17869"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14859"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18932"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764\u20101489.341"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102019\u2010315010"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0481"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1425550"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16724"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.01.1616"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010024\u201000913\u20109"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.013"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.031"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.003"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1802"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2020.05.008"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17538"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15064"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.3.29"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010024\u201002998\u20104"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18178"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010023\u201001038\u20103"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf115"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:39:00Z","timestamp":1782484740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jdv.70330"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70330","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}