{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:03:37Z","timestamp":1791065017736,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Smoking is associated with hidradenitis suppurativa (HS), but the clinical significance of smoking history is poorly understood.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To examine the impact of smoking history and change in smoking behaviour on disease severity and treatment outcomes in patients with HS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with hospital\u2010diagnosed HS from two independent prospective cohorts, the Copenhagen Hidradenitis Suppurativa Cohort (HIS\u2010COP) and the Danish Skin Cohort (DSC), were included. Data on Hurley stage, International Hidradenitis Suppurativa Severity Score System (IHS4), Dermatology Life Quality Index (DLQI), boil\u2010associated pain and disease\u2010related bother were extracted from HIS\u2010COP to assess the association between smoking status at baseline and treatment outcomes. The DSC was used to assess the effect of change in smoking status on self\u2010reported disease severity and DLQI.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In HIS\u2010COP (\n n<\/jats:italic>\n \u2009=\u2009787), current smoking (53.9%) was associated with being Hurley stage III relative to I (OR\u2009=\u20092.38, 95% CI: 1.02\u20135.56,\n p<\/jats:italic>\n \u2009=\u20090.044), higher IHS4 (OR\u2009=\u20091.05, 95% CI: 1.01\u20131.10,\n p<\/jats:italic>\n \u2009=\u20090.018), higher DLQI (OR\u2009=\u20091.06, 95% CI: 1.03\u20131.09,\n p<\/jats:italic>\n \u2009<\u20090.001) and greater overall disease\u2010related bother (OR\u2009=\u20091.14, 95% CI: 1.07\u20131.22,\n p<\/jats:italic>\n \u2009<\u20090.001) relative to never smokers when adjusted for. Increasing pack years smoked and the number of cigarettes smoked per day were significantly associated with higher IHS4 (\n p<\/jats:italic>\n \u2009<\u20090.01 and\n p<\/jats:italic>\n \u2009<\u20090.05, respectively); however, after adjusting for age and sex,\n p<\/jats:italic>\n \u2009>\u20090.05. Among patients initiated on tetracycline\u2010class treatment, current smokers had a significantly smaller mean (SD) reduction in IHS4 (2.5 (3.2) vs. 4.7 (4.9),\n p<\/jats:italic>\n \u2009<\u20090.001), DLQI (4.2 (6.2) vs. 6.0 (6.4),\n p<\/jats:italic>\n \u2009<\u20090.05) and percentage reduction in overall disease\u2010related bother (2.9 (4.0) vs. 4.3 (4.0),\n p<\/jats:italic>\n \u2009<\u20090.05), compared to non\u2010smokers at follow\u2010up. Smoking cessation and initiation both showed a trend towards increased self\u2010reported disease severity after 12\u2009months follow\u2010up; however, data were limited.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Smoking is associated with greater disease severity, poorer quality of life and worse treatment outcomes among patients with HS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.70344","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:34:08Z","timestamp":1770028448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of smoking on disease severity and treatment outcomes in hidradenitis suppurativa"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0711-4932","authenticated-orcid":false,"given":"Amanda Holmen","family":"Poulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte Georgina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdemar Wendelboe","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1545","authenticated-orcid":false,"given":"Julia\u2010Tatjana","family":"Maul","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich, University of Zurich Zurich Switzerland"},{"name":"Faculty of Medicine, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj","family":"Holgersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19435"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02475-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01552.x"},{"key":"e_1_2_13_5_1","first-page":"4","article-title":"Smoking and skin disease","volume":"15","author":"Thomsen SF","year":"2010","journal-title":"Skin Therapy 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