{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:05:19Z","timestamp":1790366719680,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti\u2010p200 pemphigoid (P200) is a rare subepidermal autoimmune blistering disease (AIBD) related to anti\u2010laminin \u03b31 autoantibodies (Abs). It has been recently reported that laminin \u03b24 was frequently recognized by sera from patients with P200.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the incidence of P200 in France using a new recombinant anti\u2010laminin \u03b24 serological assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre retrospective study was conducted in the Immunology Laboratory of the French reference centre for AIBD from January 2018 to March 2023. Sera suspected of corresponding to P200 were tested using the new anti\u2010LAMB4 cell\u2010based immunoassay (CBIA) and\/or immunoblotting (IB) on dermal extract. The incidence of P200 was then estimated based on its incidence rate relative to those of BP and pemphigus over the same period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      116 patients with sera labelling the dermal side of salt\u2010split skin by IIF and negative for other junctional AIBD were recorded. Among them, 23 patients' sera had already been tested positive for P200 by dermal IB. Thus, 93 patients' sera were tested with both the anti\u2010LAMB4 CBIA and IB: 85 were positive with the CBIA (91%) vs. 44 with IB (47%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Only two were positive with IB alone. Overall, 110 patients had anti\u2010p200 Abs. Subsequently, we compared the frequency of serological detection of P200 to that of BP and pemphigus based on data from centres that exhaustively submitted their sera to our reference laboratory. According to the incidence of BP and pemphigus in France (21.7 and 1.85 cases per million inhabitants per year, respectively), the incidence of P200 was estimated to range from 0.23 to 0.83 cases per million inhabitants per year. This corresponds to approximately 16\u201357 new cases annually in France, which is approximately 2\u2010 to 4\u2010fold more frequent than\n                      <jats:italic>epidermolysis bullosa acquisita<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that P200 may be much more frequent than initially estimated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70370","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:03:41Z","timestamp":1773011021000},"page":"1675-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence of\n                    <scp>P200<\/scp>\n                    pemphigoid: A nationwide study"],"prefix":"10.1111","volume":"40","author":[{"given":"Fabienne","family":"Jouen","sequence":"first","affiliation":[{"name":"Department of Immunology and Biotherapy Rouen University Hospital and INSERM U 1234  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Carrette","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotherapy Rouen University Hospital and INSERM U 1234  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Golinski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital and INSERM U 1234, Centre de r\u00e9f\u00e9rence des maladies bulleuses Autoimmunes, Normandie University  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Maho\u2010Vaillant","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital and INSERM U 1234, Centre de r\u00e9f\u00e9rence des maladies bulleuses Autoimmunes, Normandie University  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-0913","authenticated-orcid":false,"given":"Alexis","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital and INSERM U 1234, Centre de r\u00e9f\u00e9rence des maladies bulleuses Autoimmunes, Normandie University  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gillibert","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Rouen University Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-0255","authenticated-orcid":false,"given":"Pascal","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital and INSERM U 1234, Centre de r\u00e9f\u00e9rence des maladies bulleuses Autoimmunes, Normandie University  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-2033","authenticated-orcid":false,"given":"Vivien","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital and INSERM U 1234, Centre de r\u00e9f\u00e9rence des maladies bulleuses Autoimmunes, Normandie University  Rouen 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