{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:46:05Z","timestamp":1790358365472,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023710","name":"Hellenic Institute for the Study of Sepsis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with substantial heritability and clinical heterogeneity. Large\u2010scale genetic studies often lack deep clinical or immunological phenotyping and typically rely on unmatched biobank controls. Our study overcomes this limitation by using carefully matched healthy comparators and integrating genomic, proteomic and pQTL analyses to dissect the molecular underpinnings of HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify genetic variants associated with HS susceptibility using a genome\u2010wide association study (GWAS) in a Greek cohort and to determine whether these variants influence systemic inflammation by integrating blood proteomic profiling and protein quantitative trait locus (pQTL) mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study involving 314 HS patients and 81 age\u2010, sex\u2010 and comorbidity\u2010matched healthy comparators of European (Greek) ancestry. Genomic DNA was analysed using GWAS, and inflammatory protein levels were assessed in a subset of participants using the Olink proteomics platform. GWAS meta\u2010analysis was performed with the FinnGen biobank. Publicly available pQTL datasets were used to evaluate genetic regulation of differentially expressed proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While the Greek GWAS alone revealed suggestive genetic loci, meta\u2010analysis with FinnGen identified 60 genome\u2010wide significant loci, including novel variants near\n                      <jats:italic>HLA\u2010DRA<\/jats:italic>\n                      . Proteomic profiling uncovered 51 differentially expressed proteins (DEPs), with only four upregulated in HS patients. Severity\u2010correlated proteins included IL\u20106, IL\u201017A and FGF21. Integration with pQTL data showed enrichment of HS\u2010associated SNPs among pQTLs regulating DEPs, supporting the genetic basis for systemic inflammation in HS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings support a dual model of HS pathogenesis involving genetically driven epithelial dysfunction and systemic inflammation. The identification of\n                      <jats:italic>HLA\u2010DRA<\/jats:italic>\n                      \u2010associated variants raises the possibility that HS may share features with autoimmune diseases, while the proteomic profile dominated by innate cytokines suggests that an autoinflammatory component is also involved.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70390","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:06:44Z","timestamp":1772993204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genomic and proteomic insights into hidradenitis suppurativa"],"prefix":"10.1111","author":[{"given":"Maria","family":"Argyropoulou","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine National and Kapodistrian University of Athens, Medical School  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Stylianakis","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine National and Kapodistrian University of Athens, Medical School  Greece"},{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis","family":"Rica\u00f1o\u2010Ponce","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Keur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-1556","authenticated-orcid":false,"given":"Theodora","family":"Kanni","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine National and Kapodistrian University of Athens, Medical School  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Stergianou","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine National and Kapodistrian University of Athens, Medical School  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen the Netherlands"},{"name":"Department of Immunology and Metabolism Life and Medical Sciences Institute (LIMES), University of Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-3911","authenticated-orcid":false,"given":"Evangelos J.","family":"Giamarellos\u2010Bourboulis","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine National and Kapodistrian University of Athens, Medical School  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