{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:58:37Z","timestamp":1788026317169,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023331","name":"LEO Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab and tralokinumab for atopic dermatitis (AD) target the type 2 axis through different mechanisms of action, which may lead to variation in effectiveness and safety. Head\u2010to\u2010head trials, however, are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the real\u2010world effectiveness and safety of dupilumab and tralokinumab in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled biologic\u2212\/Janus kinase inhibitor\u2010na\u00efve AD patients (\u226512\u2009years) from the BioDay registry who initiated dupilumab or tralokinumab between November 2021 and September 2024. Visits were scheduled at baseline, 4\u2009weeks and every 3\u2009months up to 52\u2009weeks. Effectiveness outcomes included Eczema Area and Severity Index (EASI), weekly mean pruritus Numeric Rating Scale (NRS), treat\u2010to\u2010target thresholds (EASI\u2009\u2264\u20097; NRS\u2010pruritus\u2009\u2264\u20094, with patients discontinuing treatment considered non\u2010responders) and drug survival. Adverse events (AEs) were assessed at each visit. Inverse probability of treatment weighting (IPTW) was used to balance treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 750 patients were included (643 dupilumab; 107 tralokinumab). After IPTW, baseline characteristics were well balanced. During follow\u2010up, dupilumab patients had lower EASI scores than tralokinumab patients, although differences were not consistently statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10). NRS\u2010pruritus scores were significantly lower with dupilumab at all visits (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), mean differences did not exceed the 2\u2010point clinical relevance threshold. The probability of achieving EASI\u2009\u2264\u20097 and NRS\u2010pruritus\u2009\u2264\u20094 was higher with dupilumab (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with risk differences of 34.7% and 40.2% at 52\u2009weeks, respectively. After 52\u2009weeks, dupilumab drug survival was 92.6% vs. 70.6% for tralokinumab. Ocular surface disease incidence was similar (HR 1.0, 95% CI 0.6\u20131.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94) between treatments, leading to discontinuation of dupilumab in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923 (3.4\/100 PY) and tralokinumab in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095 (5.4\/100 PY).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real\u2010world comparison, dupilumab provided superior effectiveness compared with tralokinumab. In responders continuing treatment, EASI and NRS\u2010pruritus differences were small. More substantial differences were observed when treatment targets EASI\u2009\u2264\u20097 and NRS\u2010pruritus\u2009\u2264\u20094, and discontinuation rates were taken into account.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70442","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:31:28Z","timestamp":1776072688000},"page":"1359-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dupilumab versus tralokinumab in atopic dermatitis: A propensity score adjusted comparison from BioDay"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-7771","authenticated-orcid":false,"given":"Lian F.","family":"van der Gang","sequence":"first","affiliation":[{"name":"National Expertise Centre for Atopic Dermatitis, Department of Dermatology and Allergology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas P. A.","family":"Zuithoff","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge M.","family":"Haeck","sequence":"additional","affiliation":[{"name":"National Expertise Centre for Atopic Dermatitis, Department of Dermatology and Allergology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veroniek E. M.","family":"Harbers","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Stadhouders\u2010Keet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Reinier de Graaf Hospital  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaziena","family":"Politiek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Frisius Medical Centre  Leeuwarden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Oosting","sequence":"additional","affiliation":[{"name":"Department of Dermatology Spaarne Gasthuis  Hoofddorp The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke M. T.","family":"van Lynden\u2010van Nes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Meander Medical Centre  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoo\u2010Yin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Isala Hospital  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Moon","family":"van Tuyll van Serooskerken","sequence":"additional","affiliation":[{"name":"Department of Dermatology Haga Hospital  Den Haag The Netherlands"},{"name":"Department of Dermatology Juliana Pediatric Hospital  Den Haag The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiarra M.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Dermatology IJsselland Hospital  Capelle aan den IJssel The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-2914","authenticated-orcid":false,"given":"Antoni","family":"Gostynski","sequence":"additional","affiliation":[{"name":"Departement of Dermatology Maastricht University Medical Centre+  Maastricht The Netherlands"},{"name":"GROW \u2010 Research Institute for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annebeth","family":"Flinterman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Diakonessenhuis  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Velstra","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter R. 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