{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:05:59Z","timestamp":1789049159410,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021\u2010124430OA\u2010I00"],"award-info":[{"award-number":["PID2021\u2010124430OA\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011596","name":"Conselleria d'Educaci\u00f3, Investigaci\u00f3, Cultura i Esport","doi-asserted-by":"publisher","award":["CIAICO\/2023\/149"],"award-info":[{"award-number":["CIAICO\/2023\/149"]}],"id":[{"id":"10.13039\/501100011596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IMP\/00019"],"award-info":[{"award-number":["IMP\/00019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is an immune\u2010mediated inflammatory disease driven by dysregulated crosstalk between immune cells and skin\u2010resident cell populations, particularly keratinocytes and fibroblasts. However, transcriptomic findings across studies remain heterogeneous and incompletely integrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To integrate transcriptomic evidence across independent studies to define reproducible immune\u2010gene expression patterns in plaque psoriasis and identify hypothesis\u2010generating pathways beyond canonical immune programmes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of transcriptomic datasets comparing lesional psoriatic skin with non\u2010lesional skin and healthy controls. All analyses were restricted a priori to a curated set of immune\u2010related genes. Forty\u2010four independent studies comprising 975 samples were harmonized; differential expression within each study was combined using random\u2010effects models. Functional enrichment (Reactome\/KEGG\/GO) and a systematic comparison with curated resources were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The meta\u2010analysis identified 1780 immune\u2010related genes consistently dysregulated in lesional psoriasis. Enrichment confirmed established immune programmes (e.g. IL\u201023\/Th17 signalling, cytokine\u2010mediated responses and type I interferon pathways). When cross\u2010referenced with curated disease\u2013gene resources, 1119 genes overlapped with previously reported psoriasis\u2010associated genes, whereas 661 genes were not systematically highlighted. Exploratory enrichment among the less\u2010characterized genes suggested additional processes involving glucose metabolism (gluconeogenesis), FoxO signalling and mitophagy, each supported by small gene sets and borderline adjusted p\u2010values, and therefore interpreted as hypothesis\u2010generating rather than definitive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By integrating 44 datasets under an explicit immune\u2010gene framework, this study refines consensus immune signatures in psoriasis and prioritizes metabolic and mitochondrial processes as testable hypotheses for future functional work. These findings contextualize expected immune activation and point to potential interfaces between immunity, cellular energetics and mitochondrial quality control in lesional skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70459","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:07Z","timestamp":1777379767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic meta\u2010analysis identifies core molecular pathways in plaque psoriasis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-2647","authenticated-orcid":false,"given":"Teresa","family":"Torres\u2010Moral","sequence":"first","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER) Carlos III Health Institute  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-1019","authenticated-orcid":false,"given":"Josep","family":"Riera\u2010Monroig","sequence":"additional","affiliation":[{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"},{"name":"Dermatology Department, Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-6961","authenticated-orcid":false,"given":"Gemma","family":"Tell\u2010Mart\u00ed","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER) Carlos III Health Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-5667","authenticated-orcid":false,"given":"Borja","family":"G\u00f3mez\u2010Caba\u00f1es","sequence":"additional","affiliation":[{"name":"Computational Biomedicine Laboratory Principe Felipe Research Center (CIPF)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6502-5436","authenticated-orcid":false,"given":"Jaume","family":"Bagu\u00e9","sequence":"additional","affiliation":[{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-7437","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"Catal\u00e0\u2010Senent","sequence":"additional","affiliation":[{"name":"Computational Biomedicine Laboratory Principe Felipe Research Center (CIPF)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-2428","authenticated-orcid":false,"given":"Francisco J.","family":"Roig","sequence":"additional","affiliation":[{"name":"Computational Biomedicine Laboratory Principe Felipe Research Center (CIPF)  Valencia Spain"},{"name":"Faculty of Health Sciences San Jorge University  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-0765","authenticated-orcid":false,"given":"M\u00edriam","family":"Potrony","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER) Carlos III Health Institute  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"},{"name":"Biochemistry and Molecular Genetics Service Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-5636","authenticated-orcid":false,"given":"Francisco","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Computational Biomedicine Laboratory Principe Felipe Research Center (CIPF)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-9745","authenticated-orcid":false,"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER) Carlos III Health Institute  Barcelona Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS)  Barcelona Spain"},{"name":"Dermatology Department, Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes MA","year":"2014","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Di Meglio P","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/jid.2009.173","article-title":"Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in lesional psoriatic skin","volume":"129","author":"Gudjonsson JE","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"7","key":"e_1_2_14_5_1","first-page":"1740","article-title":"Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate\u2010to\u2010severe psoriasis","volume":"130","author":"Suarez\u2010Farinas M","year":"2010","journal-title":"J Invest Dermatol"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S540848"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201018404\u20109"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435\u2010024\u201000271\u2010w"},{"key":"e_1_2_14_9_1","doi-asserted-by":"crossref","unstructured":"SolvinAO ChawlaK JenssenM OlsenLC FurbergA\u2010S DanielsenK et\u00a0al.Meta\u2010analysis of RNA sequencing data from 534 skin samples shows substantial IL\u201017 effects in non\u2010lesional psoriatic skin.medRxiv(2023).https:\/\/doi.org\/10.1101\/2023.11.03.23298021","DOI":"10.1101\/2023.11.03.23298021"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.038"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010025\u201003898\u20104"},{"key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett T","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_14_13_1","doi-asserted-by":"crossref","first-page":"D1502","DOI":"10.1093\/nar\/gkaa1062","article-title":"From ArrayExpress to BioStudies","volume":"49","author":"Sarkans U","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","journal-title":"BMJ"},{"issue":"7","key":"e_1_2_14_15_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA\u2010sequencing and microarray studies","volume":"43","author":"Ritchie ME","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"e_1_2_14_16_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA\u2010seq data with DESeq2","volume":"15","author":"Love MI","year":"2014","journal-title":"Genome Biol"},{"issue":"1","key":"e_1_2_14_17_1","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyad031","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"issue":"1","key":"e_1_2_14_18_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"e_1_2_14_19_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_14_20_1","unstructured":"Garcia\u2010GarciaF.M\u00e9todos de an\u00e1lisis de enriquecimiento funcional en estudios gen\u00f3micos.Zenodo2016.https:\/\/doi.org\/10.5281\/zenodo.7669523"},{"issue":"3","key":"e_1_2_14_21_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta\u2010analyses in R with the metafor package","volume":"36","author":"Viechtbauer W","year":"2010","journal-title":"J Stat Softw"},{"issue":"3","key":"e_1_2_14_22_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta\u2010analysis in clinical trials","volume":"7","author":"DerSimonian R","year":"1986","journal-title":"Control Clin Trials"},{"issue":"4","key":"e_1_2_14_23_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010348","article-title":"Multidimensional gene set analysis of genomic data","volume":"5","author":"Montaner D","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"e_1_2_14_24_1","first-page":"D498","article-title":"The Reactome pathway knowledgebase","volume":"48","author":"Jassal B","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_14_25_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa M","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_14_26_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner M","year":"2000","journal-title":"Nat Genet"},{"issue":"4","key":"e_1_2_14_27_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini Y","year":"2001","journal-title":"Ann Stat"},{"issue":"1","key":"e_1_2_14_28_1","doi-asserted-by":"crossref","first-page":"D1056","DOI":"10.1093\/nar\/gky1133","article-title":"Open Targets Platform: new developments and updates two years on","volume":"47","author":"Carvalho\u2010Silva D","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"9997","key":"e_1_2_14_29_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke WH","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_14_30_1","first-page":"3","article-title":"Metabolic comorbidities and psoriasis: mechanisms and clinical implications","volume":"37","author":"Gisondi P","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00243"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010022\u201004599\u20107"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109977"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.704494"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.796066"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:17Z","timestamp":1777379777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":34,"alternative-id":["10.1111\/jdv.70459"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70459","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jdv.70459"}}