{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:03:38Z","timestamp":1790330618747,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sunlight is an important environmental determinant of human physiology, though its effects on health have been studied predominantly in the context of skin disease. While ultraviolet (UV) radiation is a well\u2010established risk factor for skin cancer, evidence suggests that it may also have beneficial systemic effects. This narrative review synthesizes evidence from the past decade on the associations between sunlight and UV radiation exposure and mortality\u2010related outcomes, with a focus on internal malignancies, cardiovascular disease and infectious diseases. A comprehensive search of PubMed and Embase was conducted for English\u2010language articles published between January 2015 and June 2025. Of 148 articles identified, two duplicates were removed. After title and abstract screening, 64 full\u2010text articles were assessed for eligibility; a total of 28 studies met the inclusion criteria and were included in the final review. Among the included studies, four examined cardiovascular outcomes, 12 evaluated infectious diseases, six focused on malignancies and six assessed all\u2010cause mortality. Overall, most studies reported inverse associations between UV exposure and adverse health outcomes, suggesting potential protective effects. For example, a large cohort study found that individuals with 2000\u2009kJ\/m\n                    <jats:sup>2<\/jats:sup>\n                    higher annual solar radiation exposure had a 12% lower risk of all\u2010cause mortality. The comparator group had an average of 26\u2009days of life lost over the 15.7\u2010year follow\u2010up period. This review identifies a pattern of potential beneficial associations between UV radiation exposure and systemic health outcomes, although confounding by various parameters including the healthy user effect and socioeconomic differences. When the benefits are considered alongside the well\u2010established deleterious cutaneous effects of UV exposure, these findings underscore the need for balanced public health messaging that acknowledges the risks and potential benefits of sunlight exposure.\n                  <\/jats:p>","DOI":"10.1111\/jdv.70461","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:17:31Z","timestamp":1776680251000},"page":"1618-1625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic effects of sunlight: 10\u2010year review of cardiovascular, infection and cancer outcomes"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-3373","authenticated-orcid":false,"given":"Jasira A.","family":"Ziglar","sequence":"first","affiliation":[{"name":"The Henry W. 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Lim Division of Photobiology and Photomedicine, Department of Dermatology Henry Ford Health  Detroit Michigan USA"},{"name":"University of Missouri School of Medicine  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-6375","authenticated-orcid":false,"given":"Indermeet","family":"Kohli","sequence":"additional","affiliation":[{"name":"The Henry W. Lim Division of Photobiology and Photomedicine, Department of Dermatology Henry Ford Health  Detroit Michigan USA"},{"name":"Department of Medicine, College of Human Medicine Michigan State University  East Lansing Michigan USA"},{"name":"Department of Physics and Astronomy Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-3617","authenticated-orcid":false,"given":"Yolanda","family":"Gilaberte","sequence":"additional","affiliation":[{"name":"Department of Dermatology Miguel Servet University Hospital IIS Aragon  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-1115","authenticated-orcid":false,"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"The Henry W. 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