{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T20:14:12Z","timestamp":1792959252183,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a rare but potentially life\u2010threatening drug\u2010induced hypersensitivity reaction. Approximately 15% of patients require admission to an intensive care unit (ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify factors associated with ICU admission in patients with DRESS in order to improve risk stratification and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre retrospective cohort study including adult patients with probable or definite DRESS (RegiSCAR score \u22654) hospitalized in Greater Paris area hospitals between July 2017 and January 2023. Data were extracted from the Assistance Publique\u2010H\u00f4pitaux de Paris Health Data Warehouse, covering 39 centres. The primary endpoint was DRESS\u2010related ICU admission. Secondary endpoints included in\u2010hospital mortality and therapeutic interventions inside and outside the ICU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 207 DRESS cases were included of whom 35 (17%) required ICU admission. Median age was 58\u2009years [IQR 41\u201372], with a female predominance (62%) and a median Charlson comorbidity score of 3 [1\u20136]. Anti\u2010epileptic drugs were the most frequently implicated agents (22%). Hepatic involvement was the most common visceral manifestation (70%), followed by renal (30%), haemodynamic (6.3%), cardiac (5.3%) and pulmonary involvement (1.9%). Disease severity was classified as mild in 40%, moderate in 35% and severe in 25% of cases. Nearly, all patients received corticosteroids, predominantly topical in mild to moderate forms and systemic in severe cases. Overall, in\u2010hospital mortality was 4.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), rising to 20% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097) among ICU patients. In multivariable analysis, hospital\u2010acquired DRESS (adjusted odds ratio, aOR\u2009=\u20095.21; 95% CI [1.96; 14.1];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and DRESS severity were independently associated with ICU admission (moderate forms: aOR\u2009=\u20093.74 [1.13; 14.9] and severe forms: aOR\u2009=\u200912.5 [3.79; 51.3], versus minor forms;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly one in five hospitalized patients with DRESS required ICU management. Hospital\u2010acquired DRESS and disease severity were the main determinants of critical care admission, underscoring their prognostic importance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70505","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:54:54Z","timestamp":1778921694000},"page":"1840-1849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management and predictors of\n                    <scp>ICU<\/scp>\n                    admission in\n                    <scp>DRESS<\/scp>\n                    : A\u00a0multicentre retrospective cohort study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-2348","authenticated-orcid":false,"given":"Antoine","family":"Gaillet","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation H\u00f4pitaux Universitaires Henri Mondor \u2010 Albert Chenevier, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Layese","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB  Cr\u00e9teil France"},{"name":"Assistance Publique\u2010Hopitaux de Paris (AP\u2010HP), Henri Mondor Hospital, Clinical Research Unit  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Oubaya","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB  Cr\u00e9teil France"},{"name":"INSERM U955 Team \u00ab Viruses, Hepatology, Cancer \u00bb  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-5270","authenticated-orcid":false,"given":"Emilie","family":"Sbidian","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Des Dermatoses Bulleuses Toxiques et Toxidermies Graves TOXIBUL H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"},{"name":"Service de Dermatologie H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"},{"name":"EpiDermE Universit\u00e9 Paris Est Cr\u00e9teil Val de Marne  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-005X","authenticated-orcid":false,"given":"Vincent","family":"Descamps","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Des Dermatoses Bulleuses Toxiques et Toxidermies Graves TOXIBUL H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"},{"name":"Service de Dermatologie H\u00f4pital Bichat, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-2461","authenticated-orcid":false,"given":"Jean\u2010David","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Saint\u2010Louis, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Touron","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris 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Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-7096","authenticated-orcid":false,"given":"Saskia","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Des Dermatoses Bulleuses Toxiques et Toxidermies Graves TOXIBUL H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"},{"name":"Service de Dermatologie H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)  Cr\u00e9teil France"},{"name":"EpiDermE Universit\u00e9 Paris Est Cr\u00e9teil Val de Marne  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation H\u00f4pitaux Universitaires Henri Mondor \u2010 Albert Chenevier, 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