{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T07:37:45Z","timestamp":1792913865675,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether biologic therapies can potentially reduce the risk of transition to psoriatic arthritis (PsA) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether biologic therapy is associated with a reduced risk of incident PsA among patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary and secondary endpoints were the incidence of PsA among patients with psoriasis and the associated hazard ratio (HR) for PsA development. Pooled relative risk (RR) and HR estimates were calculated using random effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies were included, involving conventional synthetic disease\u2010modifying anti\u2010rheumatic drugs (csDMARDs), biologic DMARDS (bDMARDs), phototherapy, topical therapy and no therapy. The primary analysis showed no significant difference between bDMARDs and non\u2010biologic therapies in preventing PsA (RR: 0.71, 95% CI: 0.34, 1.51; HR: 0.71, 95% CI: 0.44, 1.17). Subgroup analyses by data source showed that a lower risk of incident PsA with bDMARDs was observed in clinical cohort studies (RR: 0.31, 95% CI: 0.11, 0.87), but not in registry studies (RR: 1.03, 95% CI: 0.44, 2.40). In sensitivity analyses excluding one influential study, a lower observed risk of PsA was identified among patients receiving bDMARDs. Among studies reporting dichotomous outcomes, treatment with interleukin\u201017 inhibitors (IL\u201017i), IL\u201023i or IL\u201012\/\u201023i was associated with a lower risk of PsA compared with tumour necrosis factor inhibitors (TNFi). IL\u201017i also showed a numerically lower risk than IL\u201012\/\u201023i. Among studies reporting continuous outcomes, IL\u201023i exposure was associated with a lower risk of PsA compared with IL\u201017i or TNFi. Similarly, IL\u201017i or IL\u201012\/\u201023i was associated with a lower risk of PsA relative to TNFi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Biologic agent was not associated with a reduced overall risk of PsA in psoriasis, but subgroup analyses by data source and biologic class suggested potential risk modification. These findings are hypothesis\u2010generating and require confirmation in prospective studies and randomized trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70540","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:41:16Z","timestamp":1780407676000},"page":"1808-1818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biologic therapies and psoriatic arthritis risk in psoriasis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8730-3993","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Guangzhou Medical University Guangzhou Women and Children's Medical Center  Guangzhou Guangdong 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