{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:40:29Z","timestamp":1791646829968,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022654","name":"HudFonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful, inflamed lesions in the apocrine gland\u2010bearing regions and systemic involvement. While inflammatory cytokines including IL\u20106 and IL\u201017A have been implicated in HS pathogenesis, the extent and clinical correlates of systemic inflammation remain incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize systemic inflammatory profiles in a well\u2010defined cohort of largely untreated HS patients and assess associations with disease severity and duration, quality of life and lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this case\u2013control, single\u2010centre study, serum samples were collected from 44 patients with HS and 44 age\u2010 and sex\u2010matched healthy controls, and 92 immune\u2010related proteins were quantified by the Olink\u00ae Target 96 Inflammation panel. Clinical parameters included age, sex, BMI, smoking status, Hurley stage, International Hidradenitis Suppurativa Severity Score System (IHS4), disease duration and Dermatology Life Quality Index (DLQI). Associations were evaluated by Spearman's correlations and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010seven inflammatory proteins were significantly different between HS patients and controls. The most significantly increased mediators included TGF\u2010\u03b1, IL\u20106, OSM, IL\u20108\/CXCL8, HGF, VEGFA and IL\u201017A. Notably, several mediators, such as TGF\u2010\u03b1, OSM, IL\u20108\/CXCL8, IL\u20107, TNFSF14 and HGF, were elevated already in mild HS. IL\u20106, IL\u201017A, CCL19, VEGFA, CCL20 increased progressively with increasing Hurley stage. IL\u20106 and HGF levels showed positive correlations with IHS4 and DLQI scores, while IL\u201017A and CCL19 were associated with longer disease duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our exploratory proteomic analysis reveals systemic inflammation across all stages of HS, including early disease. IL\u20106 and HGF were associated with severity and quality of life impairment, whereas IL\u201017A and CCL19 may reflect disease chronicity. Although the relatively small cohort and potential confounding warrant cautious interpretation, these findings reinforce the concept of HS as a systemic inflammatory disorder and support early, comprehensive management to mitigate long\u2010term burden and comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70546","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:06:05Z","timestamp":1782551165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proteomic analysis in hidradenitis suppurativa reveals systemic inflammation in all disease stages"],"prefix":"10.1111","author":[{"given":"Lotta Sandelin","family":"Francke","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Uppsala University Hospital  Uppsala Sweden"},{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala 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