{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:04:32Z","timestamp":1790366672178,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conventional photodynamic therapy (C\u2010PDT) with red light is an effective but painful treatment for patients with actinic keratoses (AKs). Simulated daylight PDT (SDL\u2010PDT) is most likely less painful, but its effectiveness has not been thoroughly investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate if SDL\u2010PDT is non\u2010inferior to C\u2010PDT in terms of effectiveness in the treatment of mild to moderate AKs. Additionally, pain perception, local skin reactions and patient preferences were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010centre, non\u2010inferiority (\u22128% margin), randomized controlled trial included adults with symmetrically distributed mild to moderate AKs across one or more anatomical sites. These sites were randomly assigned to treatment with a single session of C\u2010PDT on one half of the affected area and SDL\u2010PDT on the other half, using 5\u2010aminolevulinic acid hydrochloride as the prodrug. Pain during illumination was assessed using a 0\u201310 numeric rating scale (NRS). Patient preferences were recorded through self\u2010report forms. Follow\u2010up assessments were conducted at 3\u2009months to evaluate early treatment failure and at 1\u2009year to determine overall clearance rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 69 participants with 1458 mild to moderate AKs were treated. Most lesions (89.9%) were located on the face and scalp and were diagnosed through clinical and dermoscopic evaluation. After 1\u2009year, the clearance rate was 71.0% for SDL\u2010PDT and 85.3% for C\u2010PDT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), thus failing to demonstrate non\u2010inferiority. Illumination was reported to be more painful during C\u2010PDT (mean NRS score of 6.6) compared with SDL\u2010PDT (mean NRS score of 0.8) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). One day after treatment, 98.3% of respondents expressed a preference for SDL\u2010PDT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SDL\u2010PDT showed lower clearance rates than C\u2010PDT but caused significantly less pain. Although not supported as a primary treatment for AKs, SDL\u2010PDT may be considered for patients prioritizing treatment tolerability within shared decision\u2010making.<\/jats:p>\n                    <jats:p>\n                      This randomized controlled trial was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.researchweb.org\/\">http:\/\/www.researchweb.org\/<\/jats:ext-link>\n                      (Project ID: 264721).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70556","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:13:58Z","timestamp":1781075638000},"page":"1713-1720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simulated daylight versus conventional\n                    <scp>PDT<\/scp>\n                    for mild to moderate actinic keratoses: A randomized controlled trial"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-9291","authenticated-orcid":false,"given":"Alexandra","family":"Sj\u00f6holm","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-5644","authenticated-orcid":false,"given":"Eva","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Modin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5557","authenticated-orcid":false,"given":"Julia","family":"Fougelberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-323X","authenticated-orcid":false,"given":"Magdalena","family":"Claeson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-8535","authenticated-orcid":false,"given":"John","family":"Paoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16017"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16044"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12792"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13420"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102692"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04386.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11200.x"},{"key":"e_1_2_14_9_1","unstructured":"Gerdes Medical AG.A new concept: Simulated Daylight PDT (SDL\u2010PDT) with IndoorLux\u00a9. 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