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This review provides a compartment\u2010based, clinically oriented overview of human skin embryology, linking key developmental pathways to normal structure and inherited skin disorders. The epidermis arises from surface ectoderm through the coordinated activity of bone morphogenetic protein (BMP) and Wnt signalling, with p63 maintaining the basal progenitor compartment required for stratification. Subsequent keratinocyte differentiation, cornification and barrier maturation also depend on Notch, lipid\u2010processing and desquamation pathways. Disruption of these sequential events helps explain epidermal mosaic disorders and congenital ichthyoses. In parallel, melanocytes derive from neural crest precursors and colonize the developing epidermis and hair follicles through microphthalmia\u2010associated transcription factor (MITF)\u2010centred melanocytic programmes; abnormal migration, survival or pigment production underlies several congenital pigmentary disorders. The dermal\u2013epidermal junction forms as hemidesmosomes and collagen VII\u2010containing anchoring fibrils progressively secure adhesion between epidermis and dermis; defects in these structures underlie inherited forms of epidermolysis bullosa. The dermis develops from BMP\u2010patterned mesenchyme into papillary and reticular compartments, where fibroblast differentiation, extracellular matrix production, vascularization and foetal repair programmes shape connective tissue strength, vascular patterning and wound\u2010healing behaviour. Disruption of these processes contributes to connective tissue disorders, vascular anomalies and congenital defects of repair. The hypodermis forms through progressive adipogenic differentiation, from early mesenchymal commitment to later peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3)\u2010mediated adipocyte maturation, with disruption reflected clinically by lipodystrophy syndromes. Finally, skin appendages arise through reciprocal epithelial\u2013mesenchymal interactions, initiated by Wnt\/\u03b2\u2010catenin signalling and refined by ectodysplasin\/NF\u2010\u03baB, Sonic Hedgehog, Notch and connexin\u2010mediated pathways. Defects in these shared developmental programmes provide the basis for ectodermal dysplasias. Understanding this developmental trajectory provides a unifying framework for interpreting skin disease, clarifying how timing, context and cellular origin shape clinical outcomes.<\/jats:p>","DOI":"10.1111\/jdv.70603","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:43:14Z","timestamp":1783320194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous embryology: Physiological basis and clinical implications"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-0595","authenticated-orcid":false,"given":"Francisco","family":"Martins","sequence":"first","affiliation":[{"name":"Coimbra Local Health Unit, Dermatology Department University Hospital  Coimbra 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