{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:31:36Z","timestamp":1790893896966,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R307\u20102018\u20103672"],"award-info":[{"award-number":["R307\u20102018\u20103672"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is linked to an increased risk of cardiovascular disease, but the impact of psoriasis on cardiac structure and function has been less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess cardiac structure, function and cardiometabolic risk factors in individuals with psoriasis compared with matched controls and across psoriasis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis of 1010 adults with psoriasis from the prospective PSOCADIA cohort and 1010 age\u2010 and sex\u2010matched controls without inflammatory skin disease. Participants underwent clinical assessment and transthoracic echocardiography. Cardiac abnormalities assessed included hypertrophy, valvular disease, systolic and diastolic dysfunction, and myocardial dysfunction defined by global longitudinal strain (GLS) &lt;16%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite well\u2010managed skin disease, individuals with psoriasis had more prevalent myocardial dysfunction by abnormal GLS (16.7% vs. 6.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with controls. This association persisted after adjustment for cardiometabolic risk factors and atherosclerotic cardiovascular disease. Cardiac structure and function were largely similar across psoriasis severity. Higher body mass index and diabetes were independently associated with myocardial dysfunction in psoriasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with psoriasis, even with well\u2010managed skin disease, exhibit a higher burden of myocardial dysfunction compared with controls, independent of cardiometabolic comorbidity. The prevalence was similar across psoriasis severity, highlighting the importance of cardiovascular assessment in all patients with psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                    <\/jats:title>\n                    <jats:p>NCT04950218 (Prevalence and risk factors asSOciated with CArdiac comorbiDIty in psoriAsis, registered on 6 July 2021).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70609","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:41:57Z","timestamp":1784288517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac structure and function in psoriasis: A cross\u2010sectional analysis of the\n                    <scp>PSOCADIA<\/scp>\n                    study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-6862","authenticated-orcid":false,"given":"Maria","family":"Dons","sequence":"first","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Sengel\u00f8v","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer Grundtvig","family":"Skaarup","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas Dyrby","family":"Johansen","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats C. H.","family":"Lassen","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"B\u00f8gh\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-416X","authenticated-orcid":false,"given":"Filip Soeskov","family":"Davidovski","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Borchsenius","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study, Copenhagen University Hospital \u2013 Bispebjerg &amp; Frederiksberg University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm Boje","family":"Jensen","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study, Copenhagen University Hospital \u2013 Bispebjerg &amp; Frederiksberg University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[{"name":"Copenhagen City Heart Study, Copenhagen University Hospital \u2013 Bispebjerg &amp; Frederiksberg University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer V.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology Copenhagen University Hospital \u2013 Bispebjerg &amp; Frederiksberg, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Riis","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany N.","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Imaging, Department of Cardiovascular Medicine Heart and Vascular Center, Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev &amp; Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9680","authenticated-orcid":false,"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2013 Herlev &amp; Gentofte  Copenhagen Denmark"},{"name":"Copenhagen Research Group for Inflammatory Skin, Copenhagen University Hospital \u2013 Herlev &amp; Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Biering\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2010 Herlev &amp; Gentofte, University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010020\u201001346\u20106"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.009"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1735"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.2859"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp567"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.63379"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.113"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005521"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102014\u2010305538"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003792"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.09.819"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.03.001"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554\u2010020\u201001906\u20105"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.026"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.008"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.03.011"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab032"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.70047"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2019.41566"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010024\u201002456\u20109"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/03946320221111131"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112440"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcae096"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv185"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.2868"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12123"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13649"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010024\u201001098\u2010z"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz009"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13152"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388\u20109842(02)00121\u20106"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000077913.60364.D2"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20705"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20786"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2025.101832"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.70376"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936\u2010025\u201001130\u20101"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000677"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy723"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107477"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.70609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.70609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:41:58Z","timestamp":1784288518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.70609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":41,"alternative-id":["10.1111\/jdv.70609"],"URL":"https:\/\/doi.org\/10.1111\/jdv.70609","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jdv.70609"}}