{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:24Z","timestamp":1785254424958,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dermoscopy achieves high sensitivity for melanoma detection but remains limited by low specificity in equivocal melanocytic lesions, leading to unnecessary excisions. Line\u2010field confocal optical coherence tomography (LC\u2010OCT) is an emerging non\u2010invasive imaging technique combining vertical and horizontal high\u2010resolution imaging, with potential to improve diagnostic accuracy in daily practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the added diagnostic value of LC\u2010OCT when used as a second\u2010line triage tool after clinical and dermoscopic assessment of equivocal melanocytic lesions in a real\u2010world high\u2010risk setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective diagnostic accuracy study included consecutive adult patients presenting with clinically and\/or dermoscopically equivocal melanocytic lesions in a tertiary referral centre. All lesions underwent clinical and dermoscopic examination followed by LC\u2010OCT imaging. Reflectance confocal microscopy\u2010guided management decisions independently of LC\u2010OCT. Histopathology served as the reference standard for excised lesions, while stability during digital dermoscopic follow\u2010up was considered indicative of benignity. Diagnostic performance of dermoscopy alone and dermoscopy combined with LC\u2010OCT was assessed using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 227 lesions from 178 patients were included, of which 76 (33.5%) were melanomas. Dermoscopy alone showed high sensitivity (96.1%) but low specificity (32.5%). The addition of LC\u2010OCT maintained high sensitivity (94.7%) while significantly improving specificity (65.6%) and overall accuracy (75.3%). PPV increased from 41.7% to 58.1%, whereas NPV remained high (\u226594%). Among lesions managed by follow\u2010up, two melanomas were diagnosed after interval changes. No advanced invasive melanomas were missed with the combined approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a high\u2010risk real\u2010world setting, LC\u2010OCT significantly improves the specificity and overall diagnostic accuracy of dermoscopy for equivocal melanocytic lesions while maintaining high sensitivity. As a second\u2010line triage tool, LC\u2010OCT may reduce unnecessary excisions and support safer non\u2010invasive management strategies in melanoma surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70645","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:13:57Z","timestamp":1785251637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Added value of\n                    <scp>LC<\/scp>\n                    \u2010\n                    <scp>OCT<\/scp>\n                    in equivocal melanocytic lesions: A prospective study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5174-9932","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Lenoir","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital Cl\u00ednic de Barcelona Universitat de Barcelona  Barcelona 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Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"del Marmol","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-0659","authenticated-orcid":false,"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Tognetti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-6350","authenticated-orcid":false,"given":"Francesco","family":"Piscazzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"},{"name":"Dermatology Unit IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU de Saint\u2010\u00c9tienne Universit\u00e9 Jean Monnet  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dorado","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU de Saint\u2010\u00c9tienne Universit\u00e9 Jean Monnet  Saint\u2010\u00c9tienne 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