{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:16:11Z","timestamp":1786122971538,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173425"],"award-info":[{"award-number":["82173425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373488"],"award-info":[{"award-number":["82373488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acad Dermatol Venereol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) poses a substantial global disease burden. Although previous cross\u2010sectional studies have examined lifestyle\u2010related factors associated with AD, evidence from large\u2010scale prospective cohorts, particularly regarding adult\u2010onset AD, remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether adherence to several healthy lifestyle behaviours is associated with adult\u2010onset AD incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis of a prospective cohort study was conducted within the UK Biobank. Healthy lifestyle behaviours included never smoking, no or moderate alcohol consumption, optimal sleep duration and regular physical activity. Cox proportional hazard models were used to estimate the association between these behaviours and AD incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 327,005 participants, 2464 incident AD cases occurred over a 12.49\u2010year follow\u2010up. Each behaviour was independently associated with a lower AD incidence. Adherence to all four healthy behaviours was associated with a lower incidence of AD (aHR, 0.68; 95% CI, 0.59\u20130.78) versus having none or one. In adults aged 38\u201359\u2009years, adherence to at least two behaviours was associated with lower risk of incident AD (aHR, 0.83; 95% CI, 0.70\u20130.98), whereas in adults aged 60\u201373\u2009years, a lower risk was observed primarily with adherence to all four behaviours (aHR, 0.77; 95% CI, 0.62\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adherence to these four healthy lifestyle behaviours was associated with a lower incidence of adult\u2010onset AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.70649","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:25:39Z","timestamp":1786109139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four healthy lifestyle behaviours and adult\u2010onset\n                    <scp>AD<\/scp>\n                    risk: A\u00a0prospective Study from\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1111","author":[{"given":"Boya","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Xiangya School of Public Health Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-8683","authenticated-orcid":false,"given":"Suqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Xiangya School of Public Health Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-1486","authenticated-orcid":false,"given":"Hai","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene X. Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Xiangya School of Public Health Central South University  Changsha Hunan China"},{"name":"Hunan Provincial Key Laboratory of Clinical Epidemiology Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-4897","authenticated-orcid":false,"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"},{"name":"Jiangsu Provincial Key Laboratory of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-5089","authenticated-orcid":false,"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.19580","article-title":"The global burden of atopic dermatitis: lessons from the global burden of disease study 1990\u20132017","volume":"184","author":"Laughter MR","year":"2021","journal-title":"Br J Dermatol"},{"issue":"1","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/bjd\/ljad339","article-title":"Global epidemiology of atopic dermatitis: a 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